Diabetes & Metabolic Models
Multistrain Obesity & Type 2 Diabetes Efficacy Evaluation Platform
Model Overview
Jitian Bio provides spontaneous diabetic models (e.g. db/db, ob/ob mice) and induced diabetic models (via Streptozotocin). These models exhibit stable phenotypes of hyperglycemia, insulin resistance, hyperlipidemia, and obesity, supporting target validation and screening of anti-diabetic therapeutics.
Experimental Specs
- Study Duration4w - 12w
- Species / StrainC57BL/6 Mouse
- Delivery FormLive / Frozen tissue
- Bio-AnalysisIHC / WB / Omics
Key Highlights & Advantages
Verified db/db Mouse Cohort
Leptin receptor deficient db/db mice display spontaneous obesity, severe insulin resistance, and fatty liver disease by 4-5 weeks of age.
Highly Uniform STZ Inductions
Utilizes high-purity imported Streptozotocin combined with customized diet to achieve >90% hyperglycemia induction rate.
Metabolic Cage Energy Monitoring
Supports real-time monitoring of food intake, water consumption, heat production, and physical activity under pharmacological treatments.
Preclinical Metabolic Phenotyping
Baseline parameters compared between Type 2 Diabetic models (db/db) and healthy control mice:
| Parameter (8 Weeks) | Control (m/m) | Diabetic (db/db) | Clinical Correlation |
|---|---|---|---|
| Body Weight | 24.5 ± 1.8 g | 46.2 ± 3.4 g | Mimics human morbid obesity and hyperphagia |
| Fasting Blood Glucose | 5.2 ± 0.6 mmol/L | 22.8 ± 2.9 mmol/L | Sustained severe hyperglycemia (p < 0.001) |
| OGTT Area Under Curve (AUC) | 850 ± 95 | 2350 ± 180 | Severe glucose intolerance and impaired clearance |
| Serum Insulin Level | 0.85 ± 0.12 ng/mL | 5.82 ± 0.74 ng/mL | Indicates insulin resistance and islet compensation |
Download Diabetes Validation Protocols
We provide complete protocols for OGTT, animal housing specs, and historical positive controls (Metformin, Liraglutide).