Choose a suitable model
Consider the research question, genetic background and disease phenotype to assess whether the model is suitable for testing the target mechanism.
Disease models and technical services
A systems genetics perspective on disease models and drug response
We connect genetic background, disease phenotypes and molecular mechanisms to help research institutions and pharmaceutical teams select models suited to their research questions, interpret experimental findings and inform drug efficacy predictions.
CC systems genetics: priority disease areas
- Metabolic syndrome, diabetes complications and MASHStudy metabolic susceptibility and dietary responses across CC genetic backgrounds.Study design: Gene × diet interactions · Extreme-phenotype comparisonsAnalysis: WGS / ROH · Founder haplotypes and QTL · RNA-seq / eQTL
- Tumor immunity and PD-1/PD-L1 resistanceExplore host genetic effects on tumor immunity and treatment response using CC / CCF1 backgrounds.Study design: Host immunogenetic screening · Treatment-response comparisonsAnalysis: Response QTL · Tumor RNA-seq · Immune regulatory networks
- Alzheimer’s and neurodegenerative diseasesCombine CC genetic backgrounds with AD models to study genetic modifiers and cognitive resilience.Study design: CC × AD crosses · Behavioral and pathological comparisonsAnalysis: Modifier QTL · Brain RNA-seq / eQTL
- Infection immunity and autoimmune diseasesCompare host defense, inflammation and disease susceptibility across CC strains.Study design: Susceptible–resistant strain pairs · Host–pathogen interactionsAnalysis: WGS / ROH · Founder-haplotype QTL · Immune expression networks
From model selection to interpreting results
Interpret experimental results
Connect changes in phenotype with molecular assay results to analyze the observed differences and their possible causes.
Inform drug efficacy predictions
Integrate model background, mechanism of action and experimental results to assess drug efficacy and the limits of extrapolation.
Technical services
Explore assays, analysis services and their uses by technical category.
Histopathology
Examine tissue pathology with section staining and immunohistochemistry.
- Histopathological section staining
- IHC
Molecular assays
Explore gene expression and protein measures with qPCR, ELISA and WB.
- qPCR
- ELISA
- Western blot (WB)
Multiomics
Explore molecular changes in tissues and cells through transcriptomic data in model research.
- Single-cell transcriptomics
Research reagents and consumables
阿佛丁（Avertin）三溴乙醇试剂
- Composition
- 有效成分为2,2,2-三溴乙醇（Tribromoethanol）。
- Use information
- 即用型动物实验麻醉试剂，面向小鼠短时麻醉、胚胎移植和短时外科操作。
- ChEBI
- CHEBI:135170
北京陆桥营养琼脂培养基
- Use information
- 营养琼脂（NA）类基础固体培养基，用于一般细菌的常规培养、分离、菌落形态观察及菌种纯培养。
北京正天易 BJ-40 毛细玻璃管
- Composition
- 高硼硅玻璃。
- Use information
- 用于显微注射针的拉制、胚胎移植配套和微量液体转移；透明管体便于显微观察与微量操作。
生物组织胶
- Use information
- 开瓶即用的动物实验粘合耗材，用于体表创口闭合、组织与皮肤粘合、创面辅助密封，以及组织瓣或修补材料的固定。
Compare models for your research question
Review model construction, research uses and delivery categories such as live animals or frozen tissue. Confirm specific models, strains and analysis scope through consultation.
Discuss model suitability and service scope
Share your research area and the model or analysis service you want to discuss, then contact Jitian.
Model consultation