Disease animal models

A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.

A stroke disorder caused by obstruction of blood flow to the brain, due to thrombotic (local blood clot formation) or embolic (due to a blood clot or other material traveling from another site) event.

A metabolic disorder characterized by abnormally high blood sugar levels due to diminished production of insulin or insulin resistance/desensitization.

A disease characterized by the build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.

A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Progressive kidney disorder caused by vascular damage to the glomerular capillaries, in patients with diabetes mellitus. It is usually manifested with nephritic syndrome and glomerulosclerosis.

Metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis or NASH) is a type of fatty liver disease. It often develops due to a metabolic disorder, such as obesity or diabetes, resulting in a toxic buildup of fat in the liver. It is the most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD).

Colorectal cancer is a primary or metastatic malignant neoplasm of the colon or rectum; representative histologies include carcinoma (the great majority adenocarcinoma), lymphoma and sarcoma. Its development involves multi-step genetic and epigenetic events such as APC-WNT/beta-catenin pathway lesions and interacts with chronic inflammation, diet and the gut microbiota; preclinical work relies on syngeneic allograft, human xenograft/PDX, chemically induced and genetically predisposed animal model systems.

Inflammatory bowel disease (IBD) is a class of chronic intestinal inflammatory disorders encompassing ulcerative colitis and Crohn disease; mechanistic and drug research uses chemical, adoptive-immune and gene-deficiency spontaneous colitis model families.

Asthma/airway hyperreactivity is a chronic airway disease with reversible airflow limitation, airway inflammation and hyperresponsiveness, most often type 2 (Th2/ILC2) immune driven; preclinical work uses allergen challenge, innate type-2, comorbidity/variant and transgenic model families.