Alzheimer's Disease (AD) Model
High-Fidelity Alzheimer's Pathology & Cognitive Impairment Platform
Model Overview
Jitian Bio's Alzheimer's disease models (e.g., 5XFAD, APP/PS1) reliably reproduce the three core pathological hallmarks of human AD: amyloid-beta (Aβ) plaque deposition, neurofibrillary tangles, and progressive cognitive decline. These models are widely utilized for neuroprotective drug screening, synaptic plasticity studies, and efficacy validation.
Experimental Specs
- Study Duration4w - 12w
- Species / StrainC57BL/6 Mouse
- Delivery FormLive / Frozen tissue
- Bio-AnalysisIHC / WB / Omics
Key Highlights & Advantages
Rapid & Stable Pathology Progression
5XFAD mice display amyloid plaque accumulation in the subiculum and deep cortical layers as early as 1.5-2 months of age, with rapid neuroinflammation.
Multi-dimensional Behavior Assessment
Standard tests such as Morris Water Maze, Y-Maze, and Novel Object Recognition are available to quantify spatial learning and memory deficits.
Synaptic & Electrophysiological Insights
Integrates hippocampal single-cell RNA-seq and high-precision Long-Term Potentiation (LTP) measurements to dissect drug effects on neural circuits.
Representative Validation Data & Biomarkers
Baseline characteristics and therapeutic validation parameters of Jitian Bio's AD models:
| Endpoint | Wild Type (Control) | AD Model (5XFAD) | Clinical Relevance |
|---|---|---|---|
| MWM Escape Latency (5M) | 18.5 ± 2.4 sec | 48.2 ± 5.1 sec | Significant spatial learning impairment (p < 0.01) |
| Hippocampal Aβ Plaque Area (6M) | ND (0%) | 8.4 ± 1.2% | Recapitulates human amyloid deposition |
| Iba-1+ Microglia Density | Baseline | 3.2-fold increase | Indicates marked microglia activation & neuroinflammation |
| LTP Amplitude (Hippocampus) | 100% | Reduced by 42.5% | Confirms severe synaptic transmission and plasticity deficits |
Request Alzheimer's Data Package
We provide comprehensive background strain data, historical control data including maze video clips, and standard drug protocols.