colorectal cancer

About this disease

A primary or metastatic malignant neoplasm that affects the colon or rectum. Representative examples include carcinoma, lymphoma, and sarcoma.

Standard definition source：MONDO:0005575 colorectal cancer · ontology version 2026-10-06

References

1. Xiong Wei, Favier Solène, Wu Ting, Ponce Frédérique, Dumontet Charles, Albaret Marie Alexandra, Hollande Frédéric, Diaz Jean-Jacques, Mertani Hichem C., Teng Yong. Beyond Rodents: Alternative Animal Models in Colorectal Cancer Research. International Journal of Molecular Sciences. 2025.
2. Bürtin Florian, Mullins Christina S, Linnebacher Michael. Mouse models of colorectal cancer: Past, present and future perspectives. World Journal of Gastroenterology. 2020.
3. Chen Qin, Chen Qi, Tang Fenqiong. Berberine Inhibited Tumor Growth Through Suppressing the WDR54/β‐catenin Signal Pathway in Colorectal Cancer. Cell Biology International. 2026.
4. Dzhalilova Dzhuliia, Zolotova Natalia, Fokichev Nikolai, Makarova Olga, Soares Paula. Murine models of colorectal cancer: the azoxymethane (AOM)/dextran sulfate sodium (DSS) model of colitis-associated cancer. PeerJ. 2023.
5. Stastna Monika, Janeckova Lucie, Hrckulak Dusan, Kriz Vitezslav, Korinek Vladimir. Human Colorectal Cancer from the Perspective of Mouse Models. Genes. 2019.
6. Zhang Xinxin, Qian Fengyuan, Huang Yixiang, Zheng Bowen, Wang Ziran, Zhu Huanhuan, Zhang Bo. Stimuli-Responsive Calcium Phosphate Nanoreactor for Synergistic Chemo-Photothermal-Ferroptosis Therapy of Colorectal Cancer. International Journal of Nanomedicine. 2026.
7. Chen Yang, Fang Huiting, Chen Haiqin, Liu Xiaoming, Zhao Jianxin, Stanton Catherine, Ross R. Paul, Chen Wei, Yang Bo. Bifidobacterium inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation. Gut Microbes. 2025.
8. Salehi Alireza, Yaghoobi Fatemeh, Kami Mostafa, Hashemi Maivan Hamila-sadat, Habibi Hamidreza, Mehraban Mohammadreza, Gholami Sarah. Optimization of DMH-Induced Colorectal Carcinogenesis in Rats: A Systematic Meta-Review. Clinical and Experimental Gastroenterology. 2026.
9. Katona Bryson W., Weiss Jennifer M.. Chemoprevention of Colorectal Cancer. Gastroenterology. 2019.
10. Arends Mark J, White Eric S, Whitelaw C Bruce A, Jackstadt Rene, Sansom Owen J. Mouse models of intestinal cancer. The Journal of Pathology. 2015.
11. Golovko Daniel, Kedrin Dmitriy, Yilmaz Omer H., Roper Jatin. Review: US Spelling Colorectal cancer models for novel drug discovery. Expert opinion on drug discovery. 2015.
12. Kim Min Soo, Suh Kwang Wook, Hong Suntaek, Jin Wook. TrkC promotes colorectal cancer growth and metastasis. Oncotarget. 2017.
13. Pothuraju Ramesh, Khan Imran, Jain Maneesh, Bouvet Michael, Malafa Mokenge, Roy Hemant K., Kumar Sushil, Batra Surinder K.. Colorectal cancer murine models: Initiation to metastasis. Cancer letters. 2024.
14. Chen Anna, Neuwirth Ines, Herndler-Brandstetter Dietmar, Dittmer Jurgen. Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice. Cancers. 2023.
15. Yoon Kichul, Kim Nayoung. The Effect of Microbiota on Colon Carcinogenesis. Journal of Cancer Prevention. 2018.
16. Zhang Xinan, Li Zixuan, Hua Hui, Song Hao, Qian Sangni, Huang Xin, Ye Guiqin, Huang Yingyu, Wang Qin, Zheng Boan, Xu Xiaodong, Li Yiran, Zhu Yanli, Yu Liping, Hong Yeting, Yuan Hang, Zhang Jianbin. Screening of known gut microbiome-derived metabolites in anti-tumor immunity of colorectal cancer. Journal for Immunotherapy of Cancer. 2026.
17. Cho Margaret, Carter Janell, Harari Saul, Pei Zhiheng. The Interrelationships of the Gut Microbiome and Inflammation in Colorectal Carcinogenesis. Clinics in laboratory medicine. 2014.
18. Tammariello Alexandra E., Milner John A.. Mouse Models for Unraveling the Importance of Diet in Colon Cancer Prevention. The Journal of nutritional biochemistry. 2010.
19. Huang Chenmeng, Sun Chenchen, Wang Han, Wei Ying, Zhang Yufei, Li Wenfeng, Yue Aping, Yang Yajing, Wang Jiajia, Guo Jindan, Hu Zhengxi, Chi Jiangyang, Fan Yongli. Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis. iScience. 2026.
20. Bi Yang, Glymenaki Maria, Valdivia-Garcia Maria A., Wang Mu, Eng Kai Yee, Lin Edward, Gletsu-Miller Nana, Marchesi Julian R., Smits Ron, El-Bahrawy Mona, Guerra Nadia, Li Jia V.. Trimethylamine N -Oxide, a Bariatric Surgery-Associated Host-Microbial Cometabolite, Reduces Colonic Tumorigenesis in a Sex-Dependent Manner. Cellular and Molecular Gastroenterology and Hepatology. 2026.