Insights
Tumor immunology
Tumor-immunology domain studying how host genetic background shapes response to cancer immunotherapy in diverse mouse F1 panels; published work used DO×B6 F1 for the main screen and CC×B6 F1 for validation of genetically controlled checkpoint-inhibitor responses in syngeneic tumor models.
Tumor-immunology domain studying how host genetic background shapes response to cancer immunotherapy in diverse mouse F1 panels; published work used DO×B6 F1 for the main screen and CC×B6 F1 for validation of genetically controlled checkpoint-inhibitor responses in syngeneic tumor models.
Research uses
Host genetic control of variability in response to immune checkpoint therapy; linkage analysis of response-associated genomic regions (e.g., the chromosome 13 prolactin family); applicability of DO/CC F1 diversity panels as cancer immunotherapy models.