液相色谱-质谱检测（LC-MS）

What this technique is

Category

Biochemistry & immunoassay

Principle

先以液相色谱分离样品组分，再依据离子的质荷比与相对丰度进行质谱检测，用于鉴定和测量样品中的物质。

Input samples

plasma · tissue

Research questions

Not provided

Output and readout

输出色谱分离后的目标离子信号及对应化合物的定量结果。

Applicability

用于生物样品中目标小分子的定量，以及研究化合物的鉴定与纯度分析。

Limitations

定量依赖目标化合物的标准曲线及相应的样品前处理；血浆与脑组织的处理和内标条件不同，不能直接互换。

Standard concept source：OBI:0003097 · OBI · 2026-05-08

已发布模型

No published relation.

References

1. liquid chromatography mass spectrometry assay (OBI:0003097; OBI 2026-05-08)
2. Early Neuroprotective Effects of Erucic Acid and Gentisic Acid on Hippocampal Glutamate Concentrations and Alzheimer-like Molecular Alterations in an Intracerebroventricular Streptozotocin Rat Model
3. Genetic and Pharmacological Targeting of Hsp72 Overexpression/Induction in an Alzheimer's Disease Mouse Model With Combined Amyloid and Tau Pathology
4. Mitochondrial carbonic anhydrase–VB inhibition rescues brain endothelial stress and memory in Alzheimer’s disease models