Experimental methods
电生理测定
What this technique is
- Category
- Physiology & behavior
- Principle
- 记录生物细胞或组织的电压、电流及其变化,分析细胞兴奋性与突触传递。
- Input samples
- brain slices · neurons
- Research questions
- Not provided
- Output and readout
- 输出神经元电流、电位、场兴奋性突触后电位及长时程增强等指标,评价相应的电活动或突触功能。
- Applicability
- 用于脑片和神经元的电活动及突触传递研究;膜片钳和场电位记录分别对应细胞与群体层面的信号。
- Limitations
- 脑片突触反应与活体认知行为是不同层次的终点,不能直接互相替代。
Standard concept source:OBI:0002176 · OBI · 2026-05-08
已发布模型
No published relation.
References
- Electrophysiology (OBI:0002176; OBI 2026-05-08)
- electrophysiology assay (OBI:0002176), OBI 2026-05-08
- Insulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice. EMBO Molecular Medicine. 2014
- Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides. EMBO Molecular Medicine. 2016