stroke-prone spontaneously hypertensive rat
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The stroke-prone spontaneously hypertensive rat develops spontaneous hypertension-associated cerebrovascular injury and is described as a reference model for lacunar stroke, with white-matter and small-vessel damage.
Model identity
- Model name
- stroke-prone spontaneously hypertensive rat
- Species
- rat
- Strain
- stroke-prone spontaneously hypertensive rat
Biological characteristics
- Phenotype stage
- Spontaneous lesions develop with age and blood-pressure exposure; timing depends on colony and diet.
- Research questions
- Lacunar stroke; hypertension-related small-vessel disease; white-matter injury; spontaneous stroke mechanisms.
- Limitations
- The model develops spontaneous lesions rather than controlled MCA occlusion and is not an acute thromboembolic model. Colony, diet and blood pressure affect onset and lesion distribution.