bilateral common carotid artery occlusion Wistar rat

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Bilateral common carotid artery occlusion in Wistar rats produces subtotal forebrain hypoperfusion with oxidative stress and ischemic brain injury; it is a hypoperfusion model rather than a territorial MCA stroke.

Model identity

Model name: bilateral common carotid artery occlusion Wistar rat
Species: rat
Taxonomy ID: 10116
Strain: Wistar

Biological characteristics

Phenotype stage: Hypoperfusion and oxidative injury develop over hours to days; chronic white-matter changes require longer follow-up.
Research questions: Subtotal cerebral ischemia; oxidative stress; chronic hypoperfusion; white-matter injury.
Limitations: BCCAO does not reproduce an acute focal MCA infarct or penumbra. Collateral flow and occlusion completeness determine injury, so TTC focal infarct measurement is not a valid primary readout.

References

Model consultation