bilateral common carotid artery occlusion rat (strain not reported)
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Bilateral irreversible occlusion of the common carotid arteries produces subtotal forebrain ischemia with pronounced pathobiochemical disturbance and oxidative stress.
Model identity
- Model name
- bilateral common carotid artery occlusion rat (strain not reported)
- Species
- rat
Biological characteristics
- Phenotype stage
- Injury develops over hours to days; chronic changes require longer follow-up.
- Research questions
- Subtotal cerebral ischemia; oxidative stress; chronic hypoperfusion.
- Limitations
- The strain is not reported. BCCAO does not reproduce a territorial MCA infarct or penumbra, so focal TTC infarct measurement is not a valid primary readout.