two-vessel occlusion rat (strain not reported)
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Two-vessel occlusion produces global forebrain ischemia in lightly anesthetized rats and is used for delayed neuronal death studies.
Model identity
- Model name
- two-vessel occlusion rat (strain not reported)
- Species
- rat
Biological characteristics
- Phenotype stage
- Global ischemic injury and delayed neuronal death develop over hours to days.
- Research questions
- Global cerebral ischemia; delayed neuronal death; hippocampal vulnerability.
- Limitations
- This is a global ischemia model, not focal stroke, and does not have a penumbra. Strain is not reported.