two-vessel occlusion global cerebral ischemia Mongolian gerbil
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Mongolian gerbils lack a complete cerebral Circle of Willis and develop global cerebral ischemia after bilateral common carotid artery occlusion.
Model identity
- Model name
- two-vessel occlusion global cerebral ischemia Mongolian gerbil
- Species
- Mongolian gerbil
Biological characteristics
- Phenotype stage
- Global ischemic injury develops over hours to days; hippocampal injury is a characteristic endpoint.
- Research questions
- Global cerebral ischemia; hippocampal vulnerability; delayed neuronal death.
- Limitations
- This is a global ischemia model, not focal stroke, and is specific to the gerbil Circle of Willis anatomy.