unilateral common carotid artery occlusion Mongolian gerbil
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Irreversible unilateral common carotid artery occlusion in gerbils reproduces persistent global brain ischemia because of their incomplete Circle of Willis.
Model identity
- Model name
- unilateral common carotid artery occlusion Mongolian gerbil
- Species
- Mongolian gerbil
Biological characteristics
- Phenotype stage
- Global ischemic injury develops over hours to days.
- Research questions
- Persistent global cerebral ischemia; hippocampal injury.
- Limitations
- This is a global ischemia model, not focal stroke; gerbil anatomy is required and strain/source vary.