three-vessel occlusion baboon
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Permanent occlusion of both internal carotid arteries and the left vertebral artery in baboons produces chronic cerebral hypoperfusion with white-matter changes, glial activation and hippocampal neuronal loss.
Model identity
- Model name
- three-vessel occlusion baboon
- Species
- baboon (Papio anubis)
Biological characteristics
- Phenotype stage
- White-matter and hippocampal changes develop over weeks to months.
- Research questions
- Chronic cerebral hypoperfusion; white-matter injury; large-animal translational studies.
- Limitations
- A large-animal chronic hypoperfusion model, not an acute focal stroke; species availability, ethics and cost limit use.