Reagents
tamoxifen（他莫昔芬）
This content is currently available only in Chinese. 此内容暂仅提供中文。 查看中文内容 · Chinese version
- Composition
- tamoxifen（他莫昔芬）；其活性代谢物为4-hydroxytamoxifen（4-OHT）
- Use information
- 用于诱导CreER系统重组。将Cre重组酶与雌激素受体偶联后，给予tamoxifen可激活Cre活性，实现组织特异性基因敲除。文献综述报道tamoxifen诱导的Apc条件性敲除（cKO）等位基因重组可在Apc cKO/cKO Lgr5-EGFP-IRES-CreERT2和Apc cKO/cKO Villin-CreERT2动物中实现组织特异性Apc失活。实际使用方面，文献报道向Rosa26 LSL-Cas9-eGFP/+ ;Villin CreER小鼠给予tamoxifen，以在上皮细胞特异性表达Cas9；亦可通过黏膜局部给予4-OHT激活CreER，用于Villin^CreER和Lgr5^CreER小鼠的上皮特异性Apc编辑与Lgr5谱系追踪。
Reference, supply and purchase path
No verified catalog mapping exists for this reagent; reference status: unknown.
No listed sale configuration is published here. This states neither discontinuation nor current stock.
Store-homepage entry for consultation only — not a direct purchase link.
Bulk pricing and availability inquiry
Submitting an inquiry does not place an order or confirm a purchase.
No exact merchant mapping is verified for this reagent; the reference below is an internal inquiry identifier only.
Reagent：tamoxifen（他莫昔芬）
Stable id：reagent-528（Internal inquiry reference (site id; not a merchant catalog or manufacturer SKU)）
Specification: unknown (not verified)