同型对照抗体（rat IgG2a / mouse IgG2b）

Composition

与试验抗体宿主/亚型匹配的同型对照：RMP1-14 配 rat IgG2a；9D9 配 mouse IgG2b

Formulation

InVivo-grade 无菌溶液

Quality standard

abinScience 或等效厂商 InVivo-grade，内毒素受控

Use information

与试验抗体等剂量、等体积、同途径给予，用作 TGI 计算对照

Published protocol versions

• In Vivo Checkpoint Antibody Administration in Mouse Tumor Models · **Step 11: Calculate tumor growth inhibition (TGI).** · 同型对照（TGI 基线） 与试验抗体等剂量等体积给予；TGI=(1−治疗组均体积/同型对照均体积)×100%，>60% 视为生物学显著 · rat IgG2a（对应 RMP1-14）或 mouse IgG2b（对应 9D9），InVivo-grade

  Source version：protocols.io · vv1 · abinScience cheng · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

  tumor challenge
  CT26 同系移植瘤模型（BALB/c，文献参考） · Verified applicability · 结直肠癌 (CRC)（免疫功能健全宿主中结肠肿瘤免疫治疗研究的同系移植模型（CT26）；Verified applicability）
  MC38 同系移植瘤模型（C57BL/6，文献参考） · Verified applicability · 结直肠癌 (CRC)（免疫功能健全宿主中结肠肿瘤免疫治疗研究的同系移植模型（MC38）；Verified applicability）