Mmachc Gt(AZ0348)Wtsi gene-trap cblC mouse
Mmachc gene-trap heterozygotes (Gt/+) show approximately 50% lower MMACHC protein levels and elevated plasma homocysteine and methylmalonic acid. Homozygous Gt/Gt embryos were not found beyond embryonic day E3.5.
模型身份
- 模型名称
- Mmachc Gt(AZ0348)Wtsi gene-trap cblC mouse
- 物种
- mouse
- 基因型／合子状态
- Mmachc Gt(AZ0348)Wtsi
- 等位基因
- gene-trap insertion in intron 1 of Mmachc
生物学特性
- 适用研究问题
- What genetically engineered animal models exist for cblC-type methylmalonic acidemia.
- 模型局限
- Homozygous preimplantation lethality prevents postnatal studies of the Gt/Gt state. Metabolic measurements reported for viable Gt/+ animals must not be attributed to viable homozygous adults.