Mut −/−;Tg INS-CBA-G715V mouse (MUT G715V transgenic rescue)
The INS-CBA-G715V transgene on the Mut −/− background gives reduced MCM activity with moderate methylmalonic acid elevation and a normal lifespan.
模型身份
- 模型名称
- Mut −/−;Tg INS-CBA-G715V mouse (MUT G715V transgenic rescue)
- 物种
- mouse
- 基因型／合子状态
- Mut −/−; Tg INS-CBA-G715V
- 等位基因
- G715V mutant Mmut transgene under insulin/CBA expression cassette
生物学特性
- 适用研究问题
- How partial reduction of MCM activity models intermediate methylmalonic acidemia and its metabolic phenotype.
- 模型局限
- Transgene-driven activity reduction depends on expression cassette distribution; metabolite elevation is moderate relative to mut0 mice.