链脲佐菌素 (STZ)

组成

链脲佐菌素，选择性破坏胰岛 β 细胞，用于化学诱导糖尿病模型。CAS: 18883-66-4。

使用说明

科研实验；规格与库存请向店铺确认。

PubChem

CID:29327

标识来源版本

PubChem · snapshot-sha256:074dc4d8fc42bc9483ef15d79f5b2cd4c4589fb98a407fd492d9a8eec3ed1816

已发布方案版本

• 小鼠低剂量链脲佐菌素多次注射糖尿病诱导 · Prepare the buffers and solutions as described below. Please note that the STZNa-Citrate solution should be prepared imm · β 细胞毒性诱导剂（溶液配制） 柠檬酸钠缓冲液中 7.5 mg/ml · 现配、避光，配制后 15-20 分钟内使用

  来源版本：protocols.io · vv2 · Frank Brosius · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

  实验性疾病诱导
  streptozotocin-induced diabetes mouse · 已验证适用 · 糖尿病模型（Review concludes that most available models represent NPDR rather than PDR.；已验证适用） · 糖尿病肾病 (DN)（STZ 诱导糖尿病小鼠（品系按研究记载）：白蛋白尿、GBM 增厚与系膜基质扩增；已验证适用）
  streptozotocin-induced diabetes C57BL/6 mouse · 已验证适用 · 糖尿病模型（High-dose streptozotocin-induced insulin-deficient diabetic mice were used to study diabetic wound healing and the PNS mechanism; this is not a type 2 diabetes model.；已验证适用） · 糖尿病肾病 (DN)（STZ 糖尿病 C57BL/6 小鼠：HMGB1/系膜与小管间质终点；已验证适用）
  streptozotocin-induced diabetes C57BL/6J mouse · 已验证适用 · 糖尿病模型（STZ 50 mg/kg daily for 5 days; dorsal full-thickness wounds; DSCG or SP treatment.；已验证适用） · 糖尿病肾病 (DN)（STZ 糖尿病 C57BL/6J 小鼠：肾小管损伤与足细胞表型读出；已验证适用）
  high-fat diet plus streptozotocin-induced type 2 diabetes mouse (adult induction) · 已验证适用 · 2型糖尿病 (T2D)（Adult high-fat diet plus streptozotocin mouse research on hyperglycemia and diabetic kidney injury.；已验证适用） · 糖尿病肾病 (DN)（成年 HFD+STZ 小鼠：FNDC5/线粒体完整性相关的糖尿病肾损伤；已验证适用）
  high-fat diet plus streptozotocin-induced type 2 diabetes C57BL/6J mouse · 已验证适用 · 糖尿病模型（Three groups: non-diabetic, diabetic, and diabetic treated with imeglimin；已验证适用） · 2型糖尿病 (T2D)（Does aerobic exercise alleviate diabetic arterial remodeling through Sirt1?; Male C57BL/6J mice, 6 weeks old; CON, CON-Exe, T2DM and T2DM-Exe groups；已验证适用） · 糖尿病肾病 (DN)（HFD+小剂量 STZ C57BL/6J 小鼠：ACR 升高、足细胞与纤维化终点；已验证适用）