MMUT-deficient zebrafish (methylmalonic acidemia)
CRISPR/Cas9-generated MMUT-deficient zebrafish show liver and kidney mitochondriopathy, behavioural abnormalities, increased mortality and oxidative stress.
Model identity
- Model name
- MMUT-deficient zebrafish (methylmalonic acidemia)
- Species
- zebrafish
- Genotype / zygosity
- MMUT-deficient
Biological characteristics
- Research questions
- What genetically engineered animal models exist for methylmalonic acidemia and what are their characteristics.
- Limitations
- A whole-organism larval/juvenile model; metabolite handling and organ size differ from mammals, limiting direct pharmacokinetic extrapolation.