Skip to main content

Disease

metabolic disease

Disease classification：human disease; disease by developmental or physiological process

About this disease

A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Standard definition source：MONDO:0005066 metabolic disease · ontology version 2026-10-06

References

  1. Van Herck Mikhaïl A., Vonghia Luisa, Francque Sven M.. Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide. Nutrients. 2017.
  2. Wang Yun, Zheng Yue, Nishina Patsy M, Naggert Jürgen K.. A new mouse model of metabolic syndrome and associated complications. The Journal of endocrinology. 2009.
  3. Reed Emily, Lutsenko Svetlana, Bandmann Oliver. Animal models of Wilson disease. Journal of neurochemistry. 2018.
  4. Shan Shan, Liu Min, Ma Yue, Sun Meng, Wang Yue, Zou Hui. Animal models of methylmalonic acidemia: insights and challenges. Orphanet Journal of Rare Diseases. 2025.
  5. Yorek M.A.. Alternatives to the Streptozotocin-Diabetic Rodent. International review of neurobiology. 2016.
  6. Fang Longhou, Liu Chao, Miller Yury I.. Zebrafish models of dyslipidemia: Relevance to atherosclerosis and angiogenesis. Translational research : the journal of laboratory and clinical medicine. 2013.
  7. Zhang Feng, Ai Chunbo, Zhang Hao, Sun Xiaoqiang, Wang Li, Li Chao, Cai Wei, Yin Xuemei, Wang Yanxin, Li Yanwei, Lu Chengzhi, Li Zhuqing. Multi-omics profiling reveals coordinated metabolic and immuno-inflammatory remodeling in a high-fat diet and single-dose streptozotocin-induced mouse model of diabetic cardiomyopathy. BMC Cardiovascular Disorders. 2026.
  8. da Silva Xavier Gabriela, Bellomo Elisa A., McGinty James A., French Paul M., Rutter Guy A.. Animal Models of GWAS-Identified Type 2 Diabetes Genes. Journal of Diabetes Research. 2013.
  9. Kwitek Anne E.. Rat Models of Metabolic Syndrome. Methods in molecular biology (Clifton, N.J.). 2019.
  10. Zhou Rongrong, Llorente Cristina, Cao Jinling, Zaramela Livia S., Zeng Suling, Gao Bei, Li Shang-Zhen, Welch Ryan D., Huang Feng-Qing, Qi Lian-Wen, Pan Chuyue, Huang Yan, Zhou Pengchen, Beussen Iris, Zhang Ying, Bryam Gregory, Fiehn Oliver, Wang Lirui, Liu E-Hu, Yu Ruth T., Downes Michael, Evans Ronald M., Goglin Karrie, Fouts Derrick E., Brenner David A., Bode Lars, Fan Xuegong, Zengler Karsten, Schnabl Bernd. Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice. Cellular and Molecular Gastroenterology and Hepatology. 2021.
  11. Wang Bingxuan, P. Charukeshi Chandrasekera, Pippin John J.. Leptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes. Current Diabetes Reviews. 2014.
  12. Machado M V, Michelotti G A, Jewell M L, Pereira T A, Xie G, Premont R T, Diehl A M. Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. Cell Death & Disease. 2016.
  13. Glastras Sarah J., Chen Hui, Teh Rachel, McGrath Rachel T., Chen Jason, Pollock Carol A., Wong Muh Geot, Saad Sonia, Sen Utpal. Mouse Models of Diabetes, Obesity and Related Kidney Disease. PLoS ONE. 2016.
  14. Suriano Francesco, Vieira-Silva Sara, Falony Gwen, Roumain Martin, Paquot Adrien, Pelicaen Rudy, Régnier Marion, Delzenne Nathalie M., Raes Jeroen, Muccioli Giulio G., Van Hul Matthias, Cani Patrice D.. Novel insights into the genetically obese ( ob/ob ) and diabetic ( db/db ) mice: two sides of the same coin. Microbiome. 2021.
  15. Sun Xiaona, Bai Lin, Su Changyu, Ai Chunqing, Ren Xiaomeng, Kong Fanhua, Song Shuang. Depolymerized Fucoidan Alleviates High-Fat Diet-Induced Obesity in Association with Alterations in Gut Microbiota and Metabolic Profiles. Foods. 2026.
  16. Safarzaei Abdolvahed, Hafezinouri Hamid, Fanaei Hamed. Curcumin modulates the adipose FBN1–Asprosin axis and improves metabolic dysfunction in a rat model of type 2 diabetes. Metabolism Open. 2026.
  17. Shi Yiying, Yang Xianmin, Meng Fanxu, Feenstra Anton, Chen Jin, Gu Zongwen, Gao Xiang, Yao Wenqing, Dong Guozhen, Gong Liyan, Wu Han, Zhang Chuanliang, Gu Yuchao. The PTPN1/N2 Peptide Inhibitor Achieves Potent, Long-Acting Glycemic Control and Weight-Loss Dual Efficacy in Mice. ACS Omega. 2026.
  18. Schrepper Andrea, Schwarzer Michael. Ubiquitous Sirt1 overexpression is associated with preserved cardiac diastolic function and mitochondrial respiratory capacity in mice on a high-fat diet. Metabolism Open. 2026.
  19. Park Sin-Hye, Kim Eunkyeong, Kang Young-Hee. Oleanolic acid inhibits diet-induced adiposity through blocking neovascularization and macrophage accumulation involving Delta-like 4-Notch 1-nuclear factor-κB signaling. Nutrition Research and Practice. 2026.
  20. Parvaresh Kiyan, Dalloul Firas, Chen Mei-Hua, Shi Lisa J., Ali Muhammad Sarfraz, Torikai Hideyuki, Shi Weibin, Perrotta Ida Daniela. Genetic Dissection of the Obesity Paradox in Carotid Atherosclerosis Using a Hyperlipidemic Mouse Cohort. International Journal of Molecular Sciences. 2026.

Applicable models

Models come from published, verified disease–model relations only.

Model consultation