跳至主要内容

疾病

缺血性脑卒中

疾病分类：central nervous system disorder／cardiovascular disorder／nervous system disorder／stroke disorder／vascular disorder／brain disorder

疾病介绍

缺血性脑卒中是脑部血流受阻导致的卒中，可由局部血栓形成，或来自其他部位的血栓及其他物质栓塞所致。

标准定义来源：MONDO:1060198 ischemic stroke · 本体版本 2026-10-06

参考文献

  1. Belenichev Igor, Bukhtiyarova Nina, Ryzhenko Victor, Makyeyeva Lyudmyla, Morozova Oksana, Oksenych Valentyn, Kamyshnyi Oleksandr, Della-Morte David. Methodological Approaches to Experimental Evaluation of Neuroprotective Action of Potential Drugs. International Journal of Molecular Sciences. 2024.
  2. Li Shaofa, Wu Ying, Wei Huimin, Teng Jinyong, Yang Zaizhi, Chen Jufang, Liao Bao, Huang Xiaoqin, Meng Lanqing, Li Tong. An Engineered Biomimetic Nanoreactor With Cascade Functions for Targeted and Combinatorial Therapy of Ischemic Stroke. Advanced Healthcare Materials. 2026.
  3. Li Xianjia, Duan Yuxuan, Ma Yuning, Ma Yuxia, Ma Xiaoqi, Liang Xiaodong, Xin Dan. Electroacupuncture at Neiguan (PC6) and Shuigou (GV26) regulates microglial polarization and neuroinflammation through the cGAS–STING signaling pathway in ischemic stroke. IBRO Neuroscience Reports. 2026.
  4. Fluri Felix, Schuhmann Michael K, Kleinschnitz Christoph. Animal models of ischemic stroke and their application in clinical research. Drug Design, Development and Therapy. 2015.
  5. Shao Yanxin, Feng Lina, Li Yanchun, Cai Yichen, Yuan Hui, Tang Qin, Yang Mingfeng, Yang Weixia, Shi Hong, Mao Leilei. Urolithin A Exerts Neuroprotective Effects Against Ischemic Stroke by Inhibiting Oxidative Stress and Neuroinflammation. CNS Neuroscience & Therapeutics. 2026.
  6. Tuo Qing-Zhang, Lei Peng. Ferroptosis in ischemic stroke: Animal models and mechanisms. Zoological Research. 2024.
  7. Liu Fudong, McCullough Louise D.. Middle Cerebral Artery Occlusion Model in Rodents: Methods and Potential Pitfalls. Journal of Biomedicine and Biotechnology. 2011.
  8. Cheng Yue, Zhou Yuxi, Chen Yonghui, Shen Tianni, Li Yan, Chen Chen, Fan Qiuyue, Qi Jie, Li Peiying, Zhang Yueman. Cholesterol Drives IFITM3 + Microglia Activation and Induces STING Mediated Neuroinflammation After Ischemic Stroke. CNS Neuroscience & Therapeutics. 2026.
  9. Li Yanyu, Zhang Jingjing. Animal models of stroke. Animal Models and Experimental Medicine. 2021.
  10. Jin Wei-Na, Shi Samuel Xiang-Yu, Li Zhiguo, Li Minshu, Wood Kristofer, Gonzales Rayna J, Liu Qiang. Depletion of microglia exacerbates postischemic inflammation and brain injury. Journal of Cerebral Blood Flow & Metabolism. 2017.
  11. Amado Beatriz, Melo Lúcia, Pinto Raquel, Lobo Andrea, Barros Pedro, Gomes João R., Tsai Kuen-Jer. Ischemic Stroke, Lessons from the Past towards Effective Preclinical Models. Biomedicines. 2022.
  12. Washida Kazuo, Hattori Yorito, Ihara Masafumi. Animal Models of Chronic Cerebral Hypoperfusion: From Mouse to Primate. International Journal of Molecular Sciences. 2019.
  13. Bonnin Philippe, Kubis Nathalie, Charriaut-Marlangue Christiane. Collateral Supply in Preclinical Cerebral Stroke Models. Translational Stroke Research. 2021.
  14. Li Hongfei, Xiang Hairong, Li Xinyu, Xie Jiazhen, Zhao Linfeng, Yang Lan, Shi Riyi, Wang Yong, Shi Liangqin, Finetti Federica. Andrographolide Promotes Post-Ischemic Endothelial Angiogenic Activity via IL-10-Mediated M2-Like Microglia–Endothelial Crosstalk Involving Endothelial VEGFR2 Upregulation. Biology. 2026.
  15. Sommer Clemens J.. Ischemic stroke: experimental models and reality. Acta Neuropathologica. 2017.
  16. Kim Hahn Young, Back Dong Bin, Choi Bo-Ryoung, Choi Dong-Hee, Kwon Kyoung Ja, Borlongan Cesar. Rodent Models of Post-Stroke Dementia. International Journal of Molecular Sciences. 2022.
  17. Nan Yinan, Zhu Wenhao, Wang Shaoqing. Gastrodin inhibits neuronal ferroptosis by regulating mir-455–5p/ACSL4 pathway after stroke via exosome. Frontiers in Pharmacology. 2026.
  18. Ingberg Edvin, Dock Hua, Theodorsson Elvar, Theodorsson Annette, Ström Jakob O.. Method parameters’ impact on mortality and variability in mouse stroke experiments: a meta-analysis. Scientific Reports. 2016.
  19. Back Dong Bin, Kwon Kyoung Ja, Choi Dong-Hee, Shin Chan Young, Lee Jongmin, Han Seol-Heui, Kim Hahn Young. Chronic cerebral hypoperfusion induces post-stroke dementia following acute ischemic stroke in rats. Journal of Neuroinflammation. 2017.
  20. Sokolowski Jennifer D., Soldozy Sauson, Sharifi Khadijeh A., Norat Pedro, Kearns Kathryn N., Liu Lei, Williams Ashley M., Yağmurlu Kaan, Mastorakos Panagiotis, Miller G. Wilson, Kalani M. Yashar S., Park Min S., Kellogg Ryan T., Tvrdik Petr. Preclinical models of middle cerebral artery occlusion: new imaging approaches to a classic technique. Frontiers in Neurology. 2023.

适用模型

常用模型严格来自已发布且已验证的疾病—模型关联。

模型咨询