high-fat diet-fed Wistar rat
Wistar rats fed a purified high-fat diet develop features of metabolic syndrome: DIO groups show significantly increased fasting plasma glucose, plasma insulin and triglycerides versus controls.
模型身份
- 模型名称
- high-fat diet-fed Wistar rat
- 物种
- rat
- 品系
- Wistar
生物学特性
- 适用研究问题
- Whether a high-fat diet induces metabolic syndrome features in Wistar rats, including glycemic, insulin and lipid readouts.
- 模型局限
- Outbred diet-induced model; plasma adiponectin and leptin responses differ between high-fat and high-fat-fructose subgroups, so hormonal readouts are diet-composition dependent.
实验方法
实验方案
- 大鼠尾静脉血糖测定
使用Roche Accutrend Plus血糖试纸和读数仪测定大鼠尾静脉血糖。
本方案对该模型的适用性
状态：已验证适用· 证据类型：文献证据· 来源：PMID:30322196; https://pubmed.ncbi.nlm.nih.gov/30322196/
性别：雄性组织：blood
高脂喂养 Wistar 大鼠空腹血糖与代谢综合征表型监测；具体周龄以来源研究方案为准。
- 大鼠尾静脉血糖测定
使用Roche Accutrend Plus血糖试纸和读数仪测定大鼠尾静脉血糖。
本方案对该模型的适用性
状态：已验证适用· 证据类型：文献证据· 来源：PMID:30322196; https://pubmed.ncbi.nlm.nih.gov/30322196/
性别：雄性组织：blood
高脂喂养 Wistar 大鼠空腹血糖与代谢综合征表型监测；具体周龄以来源研究方案为准。
配套试剂与材料
- Accutrend Plus 血糖试纸与读数仪
血糖检测耗材与读数平台
- Accutrend Plus 血糖试纸与读数仪
血糖检测耗材与读数平台
参考文献
- High-fat diet induces metabolic syndrome features in Wistar rats (PMID:30322196)
- Rat Models of Metabolic Syndrome. Methods in Molecular Biology 2019 (PMID:31228162)
- protocols.io · v2 · Michael Hill · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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