stroke-prone spontaneously hypertensive rat
The stroke-prone spontaneously hypertensive rat develops spontaneous hypertension-associated cerebrovascular injury and is described as a reference model for lacunar stroke, with white-matter and small-vessel damage.
模型身份
- 模型名称
- stroke-prone spontaneously hypertensive rat
- 物种
- rat
- 品系
- stroke-prone spontaneously hypertensive rat
生物学特性
- 表型出现阶段
- Spontaneous lesions develop with age and blood-pressure exposure; timing depends on colony and diet.
- 适用研究问题
- Lacunar stroke; hypertension-related small-vessel disease; white-matter injury; spontaneous stroke mechanisms.
- 模型局限
- The model develops spontaneous lesions rather than controlled MCA occlusion and is not an acute thromboembolic model. Colony, diet and blood pressure affect onset and lesion distribution.