bilateral common carotid artery occlusion Wistar rat
Bilateral common carotid artery occlusion in Wistar rats produces subtotal forebrain hypoperfusion with oxidative stress and ischemic brain injury; it is a hypoperfusion model rather than a territorial MCA stroke.
模型身份
- 模型名称
- bilateral common carotid artery occlusion Wistar rat
- 物种
- rat
- NCBI Taxonomy ID
- 10116
- 品系
- Wistar
生物学特性
- 表型出现阶段
- Hypoperfusion and oxidative injury develop over hours to days; chronic white-matter changes require longer follow-up.
- 适用研究问题
- Subtotal cerebral ischemia; oxidative stress; chronic hypoperfusion; white-matter injury.
- 模型局限
- BCCAO does not reproduce an acute focal MCA infarct or penumbra. Collateral flow and occlusion completeness determine injury, so TTC focal infarct measurement is not a valid primary readout.
参考文献
- Nasehi L, Jahangiri S, Bijani S, Hosseini MJ. Promising Potential of Edaravone-Loaded Nanogel in Ameliorating of Stroke in Rats: The Modulation of Immune Response.. BioMed research international. 2026. PMID:42740718.
- Belenichev I, Bukhtiyarova N, Ryzhenko V, Makyeyeva L, Morozova O, Oksenych V, Kamyshnyi O. Methodological Approaches to Experimental Evaluation of Neuroprotective Action of Potential Drugs.. International journal of molecular sciences. 2024. PMID:39408802.
- NCBI Taxonomy official record: Rattus norvegicus (brown rat), Taxonomy ID 10116.
- ARRIVE 2.0 官方规范