three-vessel occlusion baboon
Permanent occlusion of both internal carotid arteries and the left vertebral artery in baboons produces chronic cerebral hypoperfusion with white-matter changes, glial activation and hippocampal neuronal loss.
模型身份
- 模型名称
- three-vessel occlusion baboon
- 物种
- baboon (Papio anubis)
生物学特性
- 表型出现阶段
- White-matter and hippocampal changes develop over weeks to months.
- 适用研究问题
- Chronic cerebral hypoperfusion; white-matter injury; large-animal translational studies.
- 模型局限
- A large-animal chronic hypoperfusion model, not an acute focal stroke; species availability, ethics and cost limit use.