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WOKW rat (Wistar Ottawa Karlsburg W)

A spontaneous polygenic model of the metabolic syndrome showing obesity, hypertension, dyslipidemia, glucose intolerance and hyperinsulinemia.

结局指标

血糖浓度读数。

实验动物

实验步骤

**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).

模型身份

模型名称
WOKW rat (Wistar Ottawa Karlsburg W)
物种
rat
品系
WOKW

生物学特性

适用研究问题
Which spontaneous polygenic rat strains model the full metabolic syndrome.
模型局限
Polygenic inheritance; individual trait severity varies across colonies, and the RT1u haplotype background must be controlled when comparing substrains.

实验方法

实验方案

配套试剂与材料

参考文献

  1. Rat Models of Metabolic Syndrome. Methods in Molecular Biology 2019 (PMID:31228162)
  2. protocols.io · vv2 · Michael Hill · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
  3. ARRIVE 2.0 官方规范
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