Mmachc tm1.1/tm1.1 cblC mouse (exons 3-4 lacZ replacement)
Mmachc tm1.1/tm1.1 mice survive until approximately E9.5-E15.5 and reproduce features of cblC-type methylmalonic acidemia.
模型身份
- 模型名称
- Mmachc tm1.1/tm1.1 cblC mouse (exons 3-4 lacZ replacement)
- 物种
- mouse
- 基因型／合子状态
- Mmachc tm1.1/tm1.1
- 等位基因
- exons 3-4 replaced by lacZ cassette
生物学特性
- 适用研究问题
- What genetically engineered animal models exist for cblC methylmalonic acidemia and how do they reproduce embryonic disease features.
- 模型局限
- Embryonic lethality between E9.5 and E15.5 prevents postnatal study of the homozygous null state.