跳至主要内容

high-fat diet-fed Wistar rat

Wistar rats fed a purified high-fat diet develop features of metabolic syndrome: DIO groups show significantly increased fasting plasma glucose, plasma insulin and triglycerides versus controls.

结局指标

血糖浓度读数。

实验动物

大鼠尾静脉血糖测定
性别
雄性
组织
blood
大鼠尾静脉血糖测定
性别
雄性
组织
blood

实验步骤

**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).

模型身份

模型名称
high-fat diet-fed Wistar rat
物种
rat
品系
Wistar

生物学特性

适用研究问题
Whether a high-fat diet induces metabolic syndrome features in Wistar rats, including glycemic, insulin and lipid readouts.
模型局限
Outbred diet-induced model; plasma adiponectin and leptin responses differ between high-fat and high-fat-fructose subgroups, so hormonal readouts are diet-composition dependent.

实验方法

实验方案

配套试剂与材料

参考文献

  1. High-fat diet induces metabolic syndrome features in Wistar rats (PMID:30322196)
  2. Rat Models of Metabolic Syndrome. Methods in Molecular Biology 2019 (PMID:31228162)
  3. protocols.io · vv2 · Michael Hill · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
  4. ARRIVE 2.0 官方规范
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