high-cholesterol diet-fed zebrafish
Feeding a high-cholesterol diet increases the proportion of VLDL and LDL fractions in zebrafish plasma and results in a lipoprotein profile closely resembling that of human plasma.
Model identity
- Model name
- high-cholesterol diet-fed zebrafish
- Species
- zebrafish
Biological characteristics
- Research questions
- Whether high-cholesterol feeding produces a zebrafish model relevant to early atherosclerosis and hypercholesterolemia.
- Limitations
- Diet-induced hypercholesterolemia in a small organism; lesion progression is vascular-change and lipid-profile based rather than full atheromatous plaque disease.