Diseases
大脑缺血再灌注 (MCAO) 模型
About this disease
Disease classification：central nervous system disorder; cardiovascular disorder; nervous system disorder; stroke disorder; vascular disorder; brain disorder
A stroke disorder caused by obstruction of blood flow to the brain, due to thrombotic (local blood clot formation) or embolic (due to a blood clot or other material traveling from another site) event.
Standard definition source：MONDO:1060198 ischemic stroke · ontology version 2026-10-06
Applicable models (published, verified)
- C57 小鼠 MCAO 线栓模型 · C57 小鼠短暂性 MCAO 再灌注模型用于缺血性脑损伤研究。 · Verified applicability
- SD 大鼠 MCAO 线栓模型 · SD 大鼠短暂性 MCAO 再灌注模型用于缺血性脑损伤研究。 · Verified applicability
- endothelin-1 induced focal cerebral ischemia (rat) · ET-1 applied to the MCA or intracerebrally produces lesions comparable to permanent MCAo; cortical application gives a semicircular infarct. · Verified applicability
- permanent middle cerebral artery occlusion C57BL/6 mouse · Mice on the C57BL/6 background, including fluorescent reporter and chimeric mice, underwent permanent occlusion of the distal MCA with ipsilateral common carotid ligation. · Verified applicability
- thromboembolic stroke rat · Article describes introducing homologous blood clots into the common carotid artery or through a retrograde external carotid catheter, and notes limitations of MCA occlusion models for pharmacological experiments. · Verified applicability
- transient middle cerebral artery occlusion Wistar rat · Transient MCAO for 90 min without BCCAo served as the stroke-only comparison group. · Verified applicability
- photothrombotic stroke rat · Photothrombosis is described as highly reproducible with low mortality but with near-complete lack of penumbra and simultaneous cytotoxic and vasogenic edema. · Verified applicability
- embolic middle cerebral artery occlusion rat · 大鼠脑动脉栓塞性缺血损伤与模型变异研究；血凝块与微球的复通机制分别解释。 · Verified applicability
- photothrombotic cortical stroke mouse · 小鼠光血栓性皮层梗死、继发脑区损伤及卒中后认知变化研究。 · Verified applicability
- permanent distal middle cerebral artery occlusion C57BL/6J mouse · C57BL/6J小鼠永久性远端大脑中动脉阻塞后的白质修复与功能恢复研究。 · Verified applicability
- transient middle cerebral artery occlusion C57BL/6J mouse · Male C57BL/6J mice subjected to 90 min intraluminal MCAO; sham mice underwent identical surgery without filament insertion. · Verified applicability
- middle cerebral artery occlusion Swiss mouse · Middle cerebral artery occlusion in Swiss mice; the Swiss strain category showed reduced infarct-volume variability in a meta-analysis. · Verified applicability
- microsphere embolic stroke rat · Microsphere embolic occlusion of the cerebral circulation produces multifocal embolic ischemic injury in rats. · Verified applicability
- intraluminal filament middle cerebral artery occlusion mouse (strain not reported) · Intraluminal filament MCA occlusion in mice without a reported strain; transient focal ischemia with reperfusion. · Verified applicability
- intraluminal filament middle cerebral artery occlusion rat (strain not reported) · Intraluminal suture MCA occlusion in rats without a reported strain; transient or permanent focal ischemia. · Verified applicability
- photothrombotic stroke rodent (species and strain not reported) · Photothrombotic cortical stroke in rodents without a reported species/strain; lesion-defined cortical ischemia. · Verified applicability
- thromboembolic stroke rodent (species and strain not reported) · Thromboembolic clot occlusion in rodents without a reported species/strain; fibrin-rich embolic ischemia. · Verified applicability
- endothelin-1 induced focal cerebral ischemia rodent (species and strain not reported) · Endothelin-1-induced focal cerebral ischemia in rodents without a reported species/strain; small cortical lesions. · Verified applicability
- permanent middle cerebral artery occlusion mouse (strain not reported) · Permanent middle cerebral artery occlusion in mice without a reported strain; persistent focal ischemia. · Verified applicability
- distal middle cerebral artery occlusion mouse (strain not reported) · Distal middle cerebral artery occlusion in mice without a reported strain; cortical infarct with striatal sparing. · Verified applicability
- embolic middle cerebral artery occlusion mouse (strain not reported) · Embolic/clot middle cerebral artery occlusion in mice without a reported strain; thromboembolic ischemia. · Verified applicability
- middle cerebral artery occlusion rodent (surgical technique category) · Surgical technique category for direct, cranial-window or electrocoagulation MCA occlusion in rodents. · Verified applicability
- direct mechanical middle cerebral artery occlusion rat (strain not reported) · Direct mechanical middle cerebral artery occlusion in rats without a reported strain. · Verified applicability
- bilateral common carotid artery occlusion combined with middle cerebral artery occlusion rat · Sequential transient MCAO and bilateral carotid occlusion combine territorial infarct with chronic hypoperfusion. · Verified applicability
- permanent middle cerebral artery occlusion with transient common carotid artery occlusion neonatal Wistar rat · Neonatal Wistar rat permanent MCAO with transient carotid occlusion models neonatal arterial ischemic stroke. · Verified applicability
- middle cerebral artery occlusion spontaneously hypertensive rat · Spontaneously hypertensive rat MCAO produces larger, less variable infarcts and models hypertension-related stroke. · Verified applicability
- Koizumi 入路大脑中动脉阻塞模型（啮齿类） · 脑动脉供血区缺血性损伤，可用于比较MCAO建模与再灌注表现。 · Verified applicability
- Zea Longa 入路大脑中动脉阻塞模型（啮齿类） · 脑动脉供血区缺血性损伤，可用于比较MCAO建模与再灌注表现。 · Verified applicability
- 线栓性短暂大脑中动脉阻塞模型（啮齿类） · 短暂性脑动脉阻塞及再灌注相关的局灶缺血性损伤。 · Verified applicability
- 小鼠大脑中动脉局部凝血酶血栓模型 · 脑动脉内局部凝血酶作用形成血栓，产生局灶性缺血损伤。 · Verified applicability
References
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