Diseases
炎症性肠病 (IBD)
About this disease
Disease classification:hereditary disease; digestive system disorder; intestinal disorder; immune system disorder; human disease; disease by body system or component
A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.
Standard definition source:MONDO:0005265 inflammatory bowel disease · ontology version 2026-10-06
Applicable models (published, verified)
- CC011 自发性慢性结肠炎 · CC011/Unc 自发性结肠炎作为炎症性肠病及其多基因遗传基础的研究参考。 · Verified applicability
- DSS 诱导结肠炎模型 · DSS 诱导结肠炎模型用于炎症性肠病相关急慢性结肠炎研究,不代表全部病因与表型。 · Verified applicability
- TNBS 相关结肠炎模型(大鼠,文献参考) · 炎症性肠病机制与干预研究的化学诱导结肠炎范式模型(TNBS,大鼠) · Verified applicability
- Il10 基因缺失自发性结肠炎模型(文献参考) · 免疫调节缺失驱动慢性肠道炎症机制研究的自发性结肠炎模型(Il10 缺失) · Verified applicability
- DSS 诱导结肠炎模型(BALB/c,文献参考) · DSS 剂量-效应与急性结肠炎炎症表型评价;药物/菌群干预在 BALB/c 背景结肠炎中的疗效观察。 · Verified applicability
- TNBS 诱导结肠炎模型(C57BL/6 小鼠,文献参考) · Th1/Th17 驱动透壁性结肠炎机制(Crohn 样);局部给药/纳米制剂干预疗效评价。 · Verified applicability
- 乙酸诱导结肠炎模型(Wistar 大鼠,文献参考) · 乙酸急性黏膜损伤的范围、重量变化与炎症介质评价;抗结肠炎化合物(如 MON/PEI 类给药)的短期疗效模型。 · Verified applicability
- 恶唑酮结肠炎模型(文献参考) · Th2/NKT 依赖性 UC 样炎症机制与干预评价。 · Verified applicability
- CD4+CD45RB-high T 细胞过继转输结肠炎模型(文献参考) · 适应性免疫驱动的慢性结肠炎机制;Treg/细胞因子通路干预评价。 · Verified applicability
- Muc2-/- 自发结肠炎模型(文献参考) · 黏液屏障缺陷与菌群-黏膜互作在结肠炎发生中的作用。 · Verified applicability
- SAMP1/YitFc 自发 Crohn 样回肠炎模型(文献参考) · 回肠特异性自发炎症的免疫机制与病变进展研究。 · Verified applicability
References
- Liu Wei, Zhang Meijing, Huang Jianan, Liu Sihan, Chen Ran, Li Yingqiang, Liu Jinlin, Jia Rui. Seaweed sulfated polysaccharides regulate the gut microbiota-mucosal barrier-innate immunity axis: structural heterogeneity, immunological evidence, and translational prospects. Frontiers in Immunology. 2026.
- Gao Han, Sun Mingming, Li Ai, Gu Qiaoyan, Kang Dengfeng, Feng Zhongsheng, Li Xiaoyu, Wang Xuehong, Chen Liang, Yang Hong, Cong Yingzi, Liu Zhanju. Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease. Gut Microbes. 2025.
- Ai Qi, Chen Wen, Chen Wen, Tuo Qinhui. Context-dependent roles of resistin-like molecule β in mucosal defense and inflammatory diseases. Frontiers in Immunology. 2026.
- Li Yiming, Zhao Tianjiao, Wang Shuya, Chen Qiaohui, Yang Yongqi, Shi Xiaojing, Song Xiangping, Wu Hao, Luo Yi, Cao Momo, Huang Qiong, Wu Wei, Ai Kelong. Precision inflammation targeting via myeloperoxidase mediated antioxidant melanin nanomedicines for chronic inflammation therapy. Nature Communications. 2026.
- Ancuța Diana‐Larisa, Coman Cristin. Preclinical Evaluation of Bacterial Lysates in Murine Disease Models: A Systematic Review. Immunity, Inflammation and Disease. 2026.
- Śledzikowska Zofia, Żylińska Karolina, Makaruk Natalia, Kubicka Dominika, Błotniak Filip Adam, Waszkiewicz Napoleon, Bou-Chacra Nadia Araci. The Inflamed Intestinal Barrier as a Formulation Variable in Oral Nanocarrier Design: Evidence-Informed Principles for Mucus Interaction, Epithelial Access, and Translational Testing. Pharmaceutics. 2026.
- Li Jing, Jacobse Justin, Pilat Jennifer M., Kaur Harsimran, Gu Weihong, Kang Seung Woo, Rusznak Mark, Huang Hsin-I, Barrera Julio, Oloo Pauline A., Roland Joseph T., Hawkins Caroline V., Pahnke Andrew P., Khalil Marian, Washington M. Kay, Wilson Keith T., Williams Christopher S., Peebles R. Stokes, Konnikova Liza, Choksi Yash A., Hammer Gianna Elena, Lau Ken S., Goettel Jeremy A.. Interleukin-10 production by innate lymphoid cells restricts intestinal inflammation in mice. Mucosal immunology. 2025.
- Passacatini Lucia Carmela, Caminiti Rosamaria, Mazza Valeria, Nucera Saverio, Proietti Stefania, Oppedisano Francesca, Maiuolo Jessica, Macrì Roberta, Serra Maria, Malafoglia Valentina, Marrelli Federica, Soluri Andrea, Carpenito Myriam, Tomino Carlo, Mollace Vincenzo, Ilari Sara, Muscoli Carolina, Grundmann Oliver. The Therapeutic Potential of Berry-Derived and Berry-Based Interventions in Inflammatory Bowel Disease: A Comprehensive Systematic Review of Preclinical and Clinical Evidence. Nutrients. 2026.
- Zhang Chuan, Li Miaoyu, Li Tiantian, Zang Xiaojie, Shi Haiyang, Liu Yaru, Zhang Chengcheng, Zhao Jianxin, Zhai Qixiao, Chen Wei, Tian Fengwei. A Postbiotic‐Inducing Ganoderma applanatum Polysaccharide Repairs the Intestinal Barrier via a Phocaeicola vulgatus ‐ Tridecylic Acid Axis. Advanced Science. 2026.
- Zhou Gaoshi, Zhang Mudan, Zheng Shuhui, Yang Guang, Li Li, Huang Shanshan, Zeng Zhirong, Chen Rirong, Zhang Shenghong, Chen Minhu. Transglutaminase 2 modulates inflammatory angiogenesis via vascular endothelial growth factor receptor 2 pathway in inflammatory bowel disease. Journal of Advanced Research. 2026.
- Katsandegwaza Brunette, Horsnell William, Smith Katherine, Mattner Jochen. Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease. International Journal of Molecular Sciences. 2022.
- Eichele Derrick D, Kharbanda Kusum K. Dextran sodium sulfate colitis murine model: An indispensable tool for advancing our understanding of inflammatory bowel diseases pathogenesis. World Journal of Gastroenterology. 2017.
- Klopfleisch Robert. Multiparametric and semiquantitative scoring systems for the evaluation of mouse model histopathology - a systematic review. BMC Veterinary Research. 2013.
- Dong Lei, Wang Hao, Wu Yongmin, Peng Jinyang, Lai Shaohao, Zhao Zexin, Yin Yongqi, Cai Jun, Thomatieli-Santos Ronaldo Vagner. Anti-Inflammatory Protein Hydrolysate Screened from Crayfish Shells Attenuates Colitis by Oxidative Stress Suppression, Inflammation Reduction and Barrier Reconstruction. Foods. 2026.
- Wang Rongrong, Meng Qingzhou, Wang Xishuang, Jiang Mingmin, Niu Dejun, Qin Guofei, Feng Qun, Tan Yujun, Jiao Xu, Zhang Mengdi, Gong Liyuan, Yang Wenlong, Qiu Yunshun, Yao Jingchun, Li Shirong, Liu Ming. Integrated Multi-Omics, Machine Learning, and Single-Cell Analysis Provide Insights into Potential Multi-Target Candidate Mechanisms of Combined MAGL11 and Icaritin in Alleviating Imidazole Propionate-Driven Metabolic Intestinal Injury. Drug Design, Development and Therapy. 2026.
- Zhang Tiantian, Zhang Xiaofen, Cai Huimei, Yu Mengli, Liu Qichen, Song Xin, Lin Bingru, Xu Linjie, Li Lan, Shen Zhe, Yu Chaohui, Zhang Jie. Glutaredoxin 1 promotes intestinal epithelial cell copper toxicity in inflammatory bowel disease. Redox Biology. 2026.
- Xiao Haitao, Xing Tianhang, Qiu Miao, Zhang Guangtao, Yang Gongli, Chen Wenke, Hu Die, Xue Deao, Peng Jiao, Du Bin. Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production. Journal of Advanced Research. 2025.
- Zhang Wen-feng, Yang Yan, Su Xin, Xu Da-yan, Yan Yu-li, Gao Qiao, Duan Ming-hua. Deoxyschizandrin Suppresses DSS-Induced Ulcerative Colitis in Mice. Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association. 2016.
- Niu Chun, Hua Yongli, Kang Jianguo, Li Fang, Chen Baoxia, Guo Rongxia, Wei Yanming. Gut Microbiota‐Dependent Tryptophan Metabolism Drives the Therapeutic Effects of Baitouweng Tang in Colitis via the AhR Pathway. Food Science & Nutrition. 2026.
- Rodriguez-Palacios Alex, Raffner Basson Abigail, Menghini Paola, Ezeji Jessica, Trotter Ashley, Rana Nitish, Goodman Wendy, Mahabaleshwar Ganapati H., Xin Wei, Pizarro Theresa T., Croniger Colleen M., Miron Alexander, Liu Yehe, Jenkins Michael W., Sundrud Mark S., Bederman Ilya R., Cominelli Fabio. Early coconut oil exposure suppresses chronic experimental Crohn’s disease via myristic acid and enhanced regulatory T cells. Nature Communications. 2026.