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疾病

动脉粥样硬化

疾病分类：arterial disorder／arteriosclerosis disorder／cardiovascular disorder／vascular disorder／human disease／disease by body system or component

疾病介绍

动脉粥样硬化是一种以动脉壁脂质积聚和钙沉积为特征的疾病，可导致动脉管腔部分或完全阻塞。

标准定义来源：MONDO:0005311 atherosclerosis · 本体版本 2026-10-06

参考文献

  1. Fan Jianglin, Kitajima Shuji, Watanabe Teruo, Xu Jie, Zhang Jifeng, Liu Enqi, Chen Y. Eugene. Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine. Pharmacology & therapeutics. 2014.
  2. He Xingling, Li Sijing, Chen Jiahui, Lin Liyu, Li Xinyu, Zhang Xiaojiao, Zhang Yihui, Chen Xingling, Guo Jinjian, Yang Zhongqi, Lu Lu, Ni Shihao. Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72 hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis. Advanced Science. 2026.
  3. Adingupu Damilola D., Heinonen Suvi E., Andréasson Anne-Christine, Brusberg Mikael, Ahnmark Andrea, Behrendt Margareta, Leighton Brendan, Jönsson-Rylander Ann-Cathrine. Hyperglycemia Induced by Glucokinase Deficiency Accelerates Atherosclerosis Development and Impairs Lesion Regression in Combined Heterozygous Glucokinase and the Apolipoprotein E-Knockout Mice. Journal of Diabetes Research. 2016.
  4. Geng Xiaoxiao, McKee Annalisse R., Rosa-Garrido Manuel, Cobo Isidoro, Riaz Muhammad. Mouse Models of Atherosclerosis: What They Teach Us, What They Miss, and When to Use Them. Bioengineering. 2026.
  5. Stephens Victoria R., Ameli Sharareh, Major Amy S., Wanjalla Celestine N., Jang Woongbi. Mouse Models of HIV-Associated Atherosclerosis. International Journal of Molecular Sciences. 2025.
  6. Goldberg Ira J., Sharma Gaurav, Fisher Edward A.. Atherosclerosis: Making a U Turn. Annual review of medicine. 2020.
  7. de Jong Renske J., Neullens Christopher T., Swoboda Aljoscha, Saers Melanie, Berger Philipp, Hebbar Subramanyam Sudheendra, Wiener Anastasia, Ohl Kim, Weiskirchen Ralf, Noels Heidi, Kallinich Tilmann, Guthrie Julia, Kessel Christoph, Tenbrock Klaus. Exploratory Analysis of the Inhibitory Effects of Propranolol on NLRP3 and Pyrin Inflammasomes. ACR Open Rheumatology. 2026.
  8. Winnik Stephan, Gaul Daniel S., Preitner Frédéric, Lohmann Christine, Weber Julien, Miranda Melroy X., Liu Yilei, van Tits Lambertus J., Mateos José María, Brokopp Chad E., Auwerx Johan, Thorens Bernard, Lüscher Thomas F., Matter Christian M.. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Basic Research in Cardiology. 2013.
  9. Viola Stephanie A., Siddiqua Shahnaz, Adesuyi Jesutofunmi, Jang Yebin, Ryskina Maryia, McGuire John J., Cui Huachun, Che Pulin. Proteinase-Activated Receptor 2 (PAR2) Deficiency and Cardiovascular Regulation: Context-Dependent Effects on Inflammation and Fibrosis. Current Issues in Molecular Biology. 2026.
  10. Peng Renyi, Ji Hao, Jin Libo, Lin Sue, Huang Yijiang, Xu Ke, Yang Qinsi, Sun Da, Wu Wei. Macrophage-Based Therapies for Atherosclerosis Management. Journal of Immunology Research. 2020.
  11. Chen Pei-Yu, Simons Michael. Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability. Current Atherosclerosis Reports. 2026.
  12. Zeng Linghong, Chi Jingshu, Zhu Meiqi, Hao Hong, Long Shiyin, Liu Zhenguo, Zhang Caiping, Lymperopoulos Anastasios. Rodent Models for Atherosclerosis. International Journal of Molecular Sciences. 2025.
  13. Schäfer Sarah, Zernecke Alma. CD8 + T Cells in Atherosclerosis. Cells. 2020.
  14. Gargiulo Sara, Gramanzini Matteo, Mancini Marcello, Henein Michael. Molecular Imaging of Vulnerable Atherosclerotic Plaques in Animal Models. International Journal of Molecular Sciences. 2016.
  15. Campbell Lee Ann, Rosenfeld Michael E.. Infection and Atherosclerosis Development. Archives of medical research. 2015.
  16. Li Tianhan, Dong Xin, Niu Xinyao, Zhang Haoyue, Wu Jianjun, Lu Liaoxun, Liang Yinming, Zhang Lichen. A guide to cell-type-specific Cre mouse models in atherosclerosis: from background strains to future directions. Frontiers in Cardiovascular Medicine. 2026.
  17. Tamargo Ian A., Baek Kyung In, Kim Yerin, Park Christian, Jo Hanjoong. Flow-induced reprogramming of endothelial cells in atherosclerosis. Nature Reviews. Cardiology. 2023.
  18. Chen Hung-Jen, Tas Sander W., de Winther Menno P.J.. Type-I interferons in atherosclerosis. The Journal of Experimental Medicine. 2020.
  19. Kobiyama Kouji, Saigusa Ryosuke, Ley Klaus. Vaccination against Atherosclerosis. Current opinion in immunology. 2019.
  20. Omar Abdullah, Chatterjee Tapan K., Tang Yaoliang, Hui David Y., Weintraub Neal L.. Proinflammatory phenotype of perivascular adipocytes. Arteriosclerosis, thrombosis, and vascular biology. 2014.

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