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疾病

糖尿病肾病

疾病分类：urinary system disorder／metabolic disease／kidney disorder／chronic kidney disease／human disease／disease by body system or component

疾病介绍

糖尿病肾病是糖尿病患者发生的进行性肾脏损伤，与肾小球毛细血管的血管损害有关，可伴随肾小球硬化。

标准定义来源：MONDO:0005016 diabetic kidney disease · 本体版本 2026-10-06

参考文献

  1. Noshahr Zahra Samadi, Salmani Hossein, Khajavi Rad Abolfazl, Sahebkar Amirhossein. Animal Models of Diabetes-Associated Renal Injury. Journal of Diabetes Research. 2020.
  2. Hang Xing, Ma Jiang, Wei Yu, Wang Yayun, Zang Xiaoyu, Xie Pengfei, Zhang Lili, Zhao Linhua. Renal microcirculation and mechanisms in diabetic kidney disease. Frontiers in Endocrinology. 2025.
  3. He Huijun, Wang Honglian, Chen Xiaocui, Zhong Yu, Huang Xiao Ru, Ma Ronald CW, Wang Cheng, Lan Hui-Yao. Treatment for type 2 diabetes and diabetic nephropathy by targeting Smad3 signaling. International Journal of Biological Sciences. 2024.
  4. Xie Kang, Ma Yan, Din Jingjing, Jin Yujie, Zhang Siwen, Liu Shiqiang, Yu Cui, Wu Xu, Xing Chunyan, Wang Lizhuo, Gao Jialin. Research and advances in mouse models of diabetic nephropathy: a narrative review. BMC Nephrology. 2025.
  5. Zhuang Yibo, Fu Chenlu, Guo Zheng, Xu Yan, Zhou Jun, Ni Huiping, Zhang Aihua. GABA ameliorates diabetic kidney disease-induced podocyte injury via JAML-FPR2 axis-mediated suppression of macrophage infiltration. Renal Failure. 2026.
  6. Brosius Frank C., Alpers Charles E.. New Targets for Treatment of Diabetic Nephropathy: What We Have Learned from Animal Models. Current opinion in nephrology and hypertension. 2013.
  7. Lai Yubo, Zhang Liang, Tao Wenxin, An Jieyuan, Wang Lantian, Liu Zhaoyou, Yang Guodong, Wu Pengying, Yuan Lijun. Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction. Advanced Science. 2026.
  8. Liang Jianqing, Liu Youhua. Animal Models of Kidney Disease: Challenges and Perspectives. Kidney360. 2023.
  9. Brosius Frank C., Alpers Charles E., Bottinger Erwin P., Breyer Matthew D., Coffman Thomas M., Gurley Susan B., Harris Raymond C., Kakoki Masao, Kretzler Matthias, Leiter Edward H., Levi Moshe, McIndoe Richard A., Sharma Kumar, Smithies Oliver, Susztak Katalin, Takahashi Nobuyuki, Takahashi Takamune. Mouse Models of Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN. 2009.
  10. Shahzad Zenab, Bala Niharika, Illyas Arooba, Kazory Amir, Chandrasekar Indra, Alli Abdel A.. Dapagliflozin Attenuates NKCC2 Protein Expression and Alleviates Diabetic Kidney Disease in Salt Loaded‐Hypertensive Diabetic Db/Db Mice. FASEB BioAdvances. 2026.
  11. Xu Fang, Jiang Hongwei, Li Xiaozhou, Pan Jian, Li Huiling, Wang Luxiang, Zhang Pan, Chen Junxiang, Qiu Shuangfa, Xie Yuxin, Li Yijian, Zhang Dongshan, Dong Zheng. Discovery of PRDM16‐Mediated TRPA1 Induction as the Mechanism for Low Tubulo‐Interstitial Fibrosis in Diabetic Kidney Disease. Advanced Science. 2023.
  12. Xiao Li, Xu Xiaoxuan, Zhang Fan, Wang Ming, Xu Yan, Tang Dan, Wang Jiahui, Qin Yan, Liu Yu, Tang Chengyuan, He Liyu, Greka Anna, Zhou Zhiguang, Liu Fuyou, Dong Zheng, Sun Lin. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Redox Biology. 2017.
  13. He Mengdi, Feng Weiyi, Xu Chengchen, Cheng Zhitian, Yue Rensong, Yang Maoyi, Hu Zhipeng. Renal protective effects and mechanisms of tripterygium glycosides in animal models of diabetic nephropathy: a preclinical systematic review and meta-analysis. Frontiers in Pharmacology. 2026.
  14. Kitada Munehiro, Ogura Yoshio, Koya Daisuke. Rodent models of diabetic nephropathy: their utility and limitations. International Journal of Nephrology and Renovascular Disease. 2016.
  15. Alpers Charles E., Hudkins Kelly L.. Mouse Models of Diabetic Nephropathy. Current opinion in nephrology and hypertension. 2011.
  16. Nitta Kyoko, Shi Sen, Nagai Takako, Kanasaki Megumi, Kitada Munehiro, Srivastava Swayam Prakash, Haneda Masakazu, Kanasaki Keizo, Koya Daisuke. Oral Administration of N-Acetyl-seryl-aspartyl-lysyl-proline Ameliorates Kidney Disease in Both Type 1 and Type 2 Diabetic Mice via a Therapeutic Regimen. BioMed Research International. 2016.
  17. Zeng Zhitao, Shang Jiazhen, Chai Shouyu, Zhang Xia, Lv Xincong, Han Xiaotian, Xu Yifan, Ma Baoze, Lv Zhimei, Wang Rong. S100A1 Promotes MDM2 ‐Mediated KLF15 Ubiquitination to Regulate ID1 ‐Driven Tubular Injury in Diabetic Kidney Disease. The FASEB Journal. 2026.
  18. Zhang Zehao, Xiang Meijuan, Lan Lejian, Peng Duo, You Lixia, Jia Mengmeng, Peng Jianyun. Electroacupuncture ameliorates diabetic renal injury by regulating the AMPK-autophagy signaling pathway. Iranian Journal of Basic Medical Sciences. 2026.
  19. Hu Xiaofang, Chen Wei, Yang Ming, Li Mengwei, Li Xiangyi, Ouyang Shaxi. IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy. Cellular and Molecular Life Sciences: CMLS. 2025.
  20. Giralt-López Anna, Molina-Van den Bosch Mireia, Vergara Ander, García-Carro Clara, Seron Daniel, Jacobs-Cachá Conxita, Soler Maria José. Revisiting Experimental Models of Diabetic Nephropathy. International Journal of Molecular Sciences. 2020.

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