Tcf7l2 whole-body knockout mouse (reference model)
Homozygous Tcf7l2 knockout mice die shortly after birth with a lack of stem cells in their intestinal crypts.
模型身份
- 模型名称
- Tcf7l2 whole-body knockout mouse (reference model)
- 物种
- mouse
- 基因型／合子状态
- Tcf7l2 −/−
生物学特性
- 适用研究问题
- What whole-body loss of Tcf7l2 reveals about T2D risk gene function.
- 模型局限
- Neonatal lethality with intestinal phenotype means the whole-body null cannot model adult type 2 diabetes risk; conditional lines are used for metabolic readouts.