high fat diet-induced rat model
High-fat feeding in rats can produce increased visceral adiposity, hyperinsulinemia, insulin resistance and altered lipid metabolism; glycemic progression depends on the dietary and strain context.
结局指标
血糖浓度读数。
实验动物
大鼠尾静脉血糖测定
- 组织
- blood
实验步骤
**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).
模型身份
- 模型名称
- high fat diet-induced rat model
- 物种
- rat
生物学特性
- 表型出现阶段
- The reviewed progression runs from early insulin resistance at a few weeks to hyperglycemia and dyslipidemia after prolonged feeding.
- 适用研究问题
- Dose-finding of dietary fat to model metabolic syndrome progression in rats; insulin resistance and lipid profile endpoints.
- 模型局限
- Response is strain- and diet-composition-dependent (lard vs vegetable fat, sucrose content); the reviewed construct leaves the background strain unspecified.
参考文献
- Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?. Nutrition & Diabetes. 2020. PMID:32616730
- NCBI Taxonomy official record: Rattus norvegicus (brown rat), Taxonomy ID 10116.
- protocols.io · vv2 · Michael Hill · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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