high carbohydrate diet-induced rat model
High-carbohydrate feeding in rats produces insulin resistance and impaired lipid metabolism, often without a significant increase in basal glucose or body weight. It represents an early metabolic-syndrome or prediabetes context rather than established hyperglycemic diabetes.
结局指标
血糖浓度读数。
实验动物
大鼠尾静脉血糖测定
- 组织
- blood
实验步骤
**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).
模型身份
- 模型名称
- high carbohydrate diet-induced rat model
- 物种
- rat
生物学特性
- 表型出现阶段
- Sucrose-driven changes appear within weeks; progression to overt glucose intolerance depends on duration and total caloric load.
- 适用研究问题
- Carbohydrate/sucrose-driven insulin resistance and dyslipidemia; stepwise metabolic-syndrome phenotyping.
- 模型局限
- The reviewed construct does not fix a background strain. Mild or absent fasting hyperglycemia limits its use as a model of established diabetes.
参考文献
- Biochemical and nutritional overview of diet-induced metabolic syndrome models in rats: what is the best choice?. Nutrition & Diabetes. 2020. PMID:32616730
- NCBI Taxonomy official record: Rattus norvegicus (brown rat), Taxonomy ID 10116.
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