Wistar fatty rat
The Wistar fatty rat is an autosomal recessive obese strain with leptin-resistance-type biology: hyperphagia, severe obesity, hyperinsulinemia and impaired glucose tolerance, progressing to overt diabetes in fatty homozygotes; used to study obesity with diabetic complications.
结局指标
血糖浓度读数。
实验动物
大鼠尾静脉血糖测定
- 组织
- blood
实验步骤
**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).
模型身份
- 模型名称
- Wistar fatty rat
- 物种
- rat
- 品系
- Wistar fatty
生物学特性
- 表型出现阶段
- Obesity is evident from weaning age; hyperinsulinemia and glucose intolerance develop over weeks to months; beta-cell failure and sustained hyperglycemia occur in a subset as animals age.
- 适用研究问题
- Leptin-resistant obesity, progression from hyperinsulinemia to glucose intolerance, and diabetic complication endpoints in fatty rats.
- 模型局限
- Not all fatty homozygotes become frankly hyperglycemic; the strain carries a leptin-resistance background rather than a defined human T2D gene, and substrain differences affect progression.
参考文献
- Diabetic Complications in Obese Type 2 Diabetic Rat Models. Experimental Animals. 2014. PMID:24770637
- NCBI Taxonomy official record: Rattus norvegicus (brown rat), Taxonomy ID 10116.
- protocols.io · vv2 · Michael Hill · This is an open access protocol distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
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