Diseases
代谢相关脂肪性肝炎 (MASH)
About this disease
Disease classification:hepatitis; hepatobiliary disorder; digestive system disorder; fatty liver disease; endocrine system disorder; liver disorder
Metabolic dysfunction-associated steatohepatitis (MASH, formerly known as nonalcoholic steatohepatitis or NASH) is a type of fatty liver disease. It often develops due to a metabolic disorder, such as obesity or diabetes, resulting in a toxic buildup of fat in the liver. It is the most severe form of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as nonalcoholic fatty liver disease or NAFLD).
Standard definition source:MONDO:0007027 metabolic dysfunction-associated steatohepatitis · ontology version 2026-10-06
Applicable models (published, verified)
- AMLN 饮食相关 MASH 模型(文献参考) · AMLN 饮食驱动的 MASH 进展机制与干预研究的文献参考模型 · Verified applicability
- GAN 饮食相关 MASH 模型(文献参考) · GAN 饮食诱导肥胖型活检确认 MASH(含纤维化)研究的文献参考模型 · Verified applicability
- methionine-choline-deficient (MCD) diet-fed mouse · MCD 饮食诱导小鼠:在 C57BL/6 系列品系上以甲硫氨酸-胆碱缺乏饮食快速诱导肝脏脂肪变、小叶炎症与气球样变的非肥胖型脂肪性肝炎构建 · Verified applicability
- choline-deficient L-amino acid-defined (CDAA) diet-fed mouse · CDAA 饮食诱导小鼠:胆碱缺乏左旋氨基酸定义饮食伴高脂诱发脂肪性肝炎与进展性纤维化的经典肝脏限制性构建 · Verified applicability
- db/db mouse (C57BL/6 background) · db/db 瘦素受体缺陷 C57BL/6 背景小鼠:高脂/复合打击下评估肝脏脂肪变、炎症与纤维化进展的遗传肥胖胰岛素抵抗模型 · Verified applicability
- ob/ob mouse · ob/ob 瘦素缺陷小鼠:遗传性肥胖与胰岛素抵抗背景下肝脏脂肪变及炎症/纤维化二次打击研究 · Verified applicability
- KK-Ay mouse · KK-Ay 小鼠:Ay 突变遗传性肥胖糖尿病背景上的自发脂肪性肝炎与胰岛素抵抗研究 · Verified applicability
- Zucker fatty (fa/fa) rat · Zucker fa/fa 大鼠:瘦素受体缺陷遗传肥胖大鼠的肝脏脂肪变与轻度炎症背景(纤维化进展有限) · Verified applicability
- High-fat diet-fed C57BL/6J mouse · 高脂饮食 C57BL/6J 小鼠:长期高脂喂养诱导肥胖、胰岛素抵抗伴肝脏脂肪变和低度炎症的 MASH 基础饮食模型(纤维化需二次打击) · Verified applicability
- Western diet-induced NASH C57BL/6J mouse · Western 饮食 C57BL/6J 小鼠用于研究肝脂肪变向脂肪性肝炎和肝周中央区纤维化的进展,并分析肝脂质空间分布与炎症。 · Verified applicability
- STAM (neonatal streptozotocin injection followed by high-fat diet) mouse · STAM 小鼠(新生期链脲佐菌素加成年期高脂饮食,C57BL/6):从脂肪变进展为脂肪性肝炎伴纤维化的经典复合打击模型 · Verified applicability
- Atherogenic diet-fed C57BL/6J mouse · 致动脉粥样硬化饮食(高胆固醇加胆酸盐)C57BL/6J 小鼠:高胆固醇血症驱动的脂肪性肝炎与快速纤维化模型 · Verified applicability
- DIAMOND model: Western diet with glucose-fructose sugar water-induced NASH in B6/129 mouse · DIAMOND 饮食(Western 饮食加葡萄糖-果糖糖水)同源 C57BL/6J 小鼠:非肥胖型脂肪性肝炎伴纤维化的标准商业膳食模型 · Verified applicability
- Alms1-mutant foz/foz mouse · foz/foz(Alms1 突变)小鼠加高脂/Western 饮食:瘦素抵抗肥胖伴肝脏脂肪变、炎症并易进展为脂肪性肝炎-HCC 的遗传模型 · Verified applicability
- TSOD mouse · TSOD 小鼠:无肥胖/糖尿病背景基因缺陷下自发出现 NAFLD 向脂肪性肝炎演变的多基因模型(本语料一篇原研加综述推荐) · Verified applicability
- Hepatocyte-specific Pten-deficient mouse · 肝细胞特异性 Pten 敲除小鼠:自发进展性 MASH 样脂肪性肝炎至 HCC 的遗传构建(本语料基于综述推荐纳入) · Verified applicability
- ALIOS (American lifestyle-induced obesity syndrome) model: Western diet and sedentary behaviour-induced NASH mouse · AliOS 饮食(反式脂肪加高果糖玉米糖浆并限制活动)小鼠:模拟人类 MASH 伴纤维化进展的商业膳食模型(本语料无原研实际使用记录) · Verified applicability
- db/db mouse on methionine-choline-deficient diet · db/db 小鼠叠加 MCD 饮食:在遗传肥胖胰岛素抵抗背景上加速脂肪性肝炎与纤维化的复合模型 · Verified applicability
- High-fat diet-induced NASH Sprague-Dawley rat · 高脂饮食 Sprague-Dawley 大鼠:饮食诱导大鼠脂肪性肝炎模型(肝脏脂肪变伴炎症、血清转氨酶升高) · Verified applicability
- Mc4r-deficient mouse on a high-fat diet · 研究 Mc4r 缺失与高脂饮食共同作用下的脂肪性肝炎、肝纤维化和肿瘤进展。 · Verified applicability
- CDAA diet plus carbon tetrachloride mouse · 比较联合损伤与单用 CDAA 饮食的肝组织病理,研究脂肪性肝炎相关纤维化和肿瘤进展。 · Verified applicability
- High-fat (15%) high-cholesterol (1%) diet mouse · 研究脂肪与胆固醇共同增加时的肝组织病理、肝损伤指标及脂肪组织炎症。 · Verified applicability
References
- Van Herck Mikhaïl A., Vonghia Luisa, Francque Sven M.. Animal Models of Nonalcoholic Fatty Liver Disease—A Starter’s Guide. Nutrients. 2017.
- Kim Kyung Eun, Lee Jaewoong, Shin Hyun Joo, Jeong Eun Ae, Jang Hye Min, Ahn Yu Jeong, An Hyeong Seok, Lee Jong Youl, Shin Meong Cheol, Kim Soo Kyoung, Yoo Won Gi, Kim Won Ho, Roh Gu Seob. Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice. Hepatology (Baltimore, Md.). 2023.
- Lau Jennie Ka Ching, Zhang Xiang, Yu Jun. Animal models of non‐alcoholic fatty liver disease: current perspectives and recent advances. The Journal of Pathology. 2016.
- Sanches Sheila Cristina L., Ramalho Leandra Naira Z., Augusto Marlei Josiele, da Silva Deisy Mara, Ramalho Fernando Silva. Nonalcoholic Steatohepatitis: A Search for Factual Animal Models. BioMed Research International. 2015.
- Tripathi Anupriya, Debelius Justine, Brenner David A., Karin Michael, Loomba Rohit, Schnabl Bernd, Knight Rob. The gut-liver axis and the intersection with the microbiome. Nature reviews. Gastroenterology & hepatology. 2018.
- Kumar Sudhir, Verma Alok K., Rani Richa, Sharma Akanksha, Wang Jiang, Shah Shimul A., Behari Jaideep, Gonzalez Rosa Salazar, Kohli Rohit, Gandhi Chandrashekhar R.. Hepatic deficiency of augmenter of liver regeneration predisposes to nonalcoholic steatohepatitis and fibrosis. Hepatology (Baltimore, Md.). 2020.
- Zhao Xu-Yun, Xiong Xuelian, Liu Tongyu, Mi Lin, Peng Xiaoling, Rui Crystal, Guo Liang, Li Siming, Li Xiaoying, Lin Jiandie D.. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nature Communications. 2018.
- Goossens Nicolas, Jornayvaz François R.. Translational Aspects of Diet and Non-Alcoholic Fatty Liver Disease. Nutrients. 2017.
- Santhekadur Prasanna K., Kumar Divya P., Sanyal Arun J.. PRECLINICAL MODELS OF NONALCOHOLIC FATTY LIVER DISEASE. Journal of hepatology. 2017.
- Yanguas Sara Crespo, Cogliati Bruno, Willebrords Joost, Maes Michaël, Colle Isabelle, van den Bossche Bert, de Oliveira Claudia Pinto Marques Souza, Andraus Wellington, Alves Venâncio Avancini Ferreira, Leclercq Isabelle, Vinken Mathieu. Experimental models of liver fibrosis. Archives of toxicology. 2015.
- Riordan Jesse D., Nadeau Joseph H.. Modeling progressive non-alcoholic fatty liver disease in the laboratory mouse. Mammalian Genome. 2014.
- Oseini Abdul M., Cole Banumathi K., Issa Danny, Feaver Ryan E., Sanyal Arun J.. Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis. Hepatology international. 2018.
- Wu Jian. Utilization of animal models to investigate nonalcoholic steatohepatitis-associated hepatocellular carcinoma. Oncotarget. 2016.
- Bettermann Kira, Hohensee Tabea, Haybaeck Johannes. Steatosis and Steatohepatitis: Complex Disorders. International Journal of Molecular Sciences. 2014.
- Liu Yu, Wang Da-Wei, Wang Dan, Duan Bin-Hong, Kuang Hong-Yu. Exenatide Attenuates Non-Alcoholic Steatohepatitis by Inhibiting the Pyroptosis Signaling Pathway. Frontiers in Endocrinology. 2021.
- Ibrahim Samar H., Hirsova Petra, Malhi Harmeet, Gores Gregory J.. Animal Models of Nonalcoholic Steatohepatitis: Eat, Delete, and Inflame. Digestive diseases and sciences. 2015.
- Wahlang Banrida, Beier Juliane I., Clair Heather B., Bellis-Jones Heather J., Falkner K. Cameron, McClain Craig J., Cave Matt C.. Toxicant-associated Steatohepatitis. Toxicologic pathology. 2012.
- Betrapally Naga S, Gillevet Patrick M, Bajaj Jasmohan S. Gut Microbiome and Liver Disease. Translational research : the journal of laboratory and clinical medicine. 2016.
- Takakura Kazuki, Oikawa Tsunekazu, Tomita Yoichi, Mizuno Yusuke, Nakano Masanori, Saeki Chisato, Torisu Yuichi, Saruta Masayuki. Mouse models for investigating the underlying mechanisms of nonalcoholic steatohepatitis-derived hepatocellular carcinoma. World Journal of Gastroenterology. 2018.
- Tao Rongya, Stöhr Oliver, Tok Ozlem, Andres-Hernando Ana, Qiu Wei, He Baiyu, Wang Caixia, Grøntved Lars, Burant Charles, Hui Sheng, Lanaspa Miguel A., Stefan Norbert, Copps Kyle D., White Morris F.. Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance. Nature Communications. 2025.