Spontaneously Hypertensive Rat (SHR)
Arguably the most comprehensively studied model of genetic hypertension, with predisposition to dyslipidemia as a metabolic-syndrome trait.
Model identity
- Model name
- Spontaneously Hypertensive Rat (SHR)
- Species
- rat
- Strain
- SHR
Biological characteristics
- Research questions
- Which rat strain models genetic hypertension with dyslipidemia as components of the metabolic syndrome.
- Limitations
- Selected for blood-pressure genetics; obesity/diabetes traits are not intrinsic, so it covers hypertension and dyslipidemia components rather than full metabolic syndrome.