high fat diet-induced rat model

High-fat feeding in rats can produce increased visceral adiposity, hyperinsulinemia, insulin resistance and altered lipid metabolism; glycemic progression depends on the dietary and strain context.

Outcome measures

血糖浓度读数。

Experimental animals

大鼠尾静脉血糖测定

Tissue: blood

Experimental procedures

**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).

Model identity

Model name: high fat diet-induced rat model
Species: rat

Biological characteristics

Phenotype stage: The reviewed progression runs from early insulin resistance at a few weeks to hyperglycemia and dyslipidemia after prolonged feeding.
Research questions: Dose-finding of dietary fat to model metabolic syndrome progression in rats; insulin resistance and lipid profile endpoints.
Limitations: Response is strain- and diet-composition-dependent (lard vs vegetable fat, sucrose content); the reviewed construct leaves the background strain unspecified.

Experimental methods

葡萄糖测定

Experimental protocols

大鼠尾静脉血糖测定
Measure rat tail-vein blood glucose using Roche Accutrend Plus test strips and meter.

Reagents and materials

Accutrend Plus 血糖试纸与读数仪
血糖检测耗材与读数平台

References

Model consultation