high carbohydrate diet-induced rat model

High-carbohydrate feeding in rats produces insulin resistance and impaired lipid metabolism, often without a significant increase in basal glucose or body weight. It represents an early metabolic-syndrome or prediabetes context rather than established hyperglycemic diabetes.

Outcome measures

血糖浓度读数。

Experimental animals

大鼠尾静脉血糖测定

Tissue: blood

Experimental procedures

**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).

Model identity

Model name: high carbohydrate diet-induced rat model
Species: rat

Biological characteristics

Phenotype stage: Sucrose-driven changes appear within weeks; progression to overt glucose intolerance depends on duration and total caloric load.
Research questions: Carbohydrate/sucrose-driven insulin resistance and dyslipidemia; stepwise metabolic-syndrome phenotyping.
Limitations: The reviewed construct does not fix a background strain. Mild or absent fasting hyperglycemia limits its use as a model of established diabetes.

Experimental methods

葡萄糖测定

Experimental protocols

大鼠尾静脉血糖测定
Measure rat tail-vein blood glucose using Roche Accutrend Plus test strips and meter.

Reagents and materials

Accutrend Plus 血糖试纸与读数仪
血糖检测耗材与读数平台

References

Model consultation