Wistar fatty rat

The Wistar fatty rat is an autosomal recessive obese strain with leptin-resistance-type biology: hyperphagia, severe obesity, hyperinsulinemia and impaired glucose tolerance, progressing to overt diabetes in fatty homozygotes; used to study obesity with diabetic complications.

Outcome measures

血糖浓度读数。

Experimental animals

大鼠尾静脉血糖测定

Tissue: blood

Experimental procedures

**Measurement of Blood Glucose ** **Measurement of Blood Glucose ** Blood samples were collected from the tail vein for the determination of blood glucose levels using Accutrend Plus test strips and meter (Roche).

Model identity

Model name: Wistar fatty rat
Species: rat
Strain: Wistar fatty

Biological characteristics

Phenotype stage: Obesity is evident from weaning age; hyperinsulinemia and glucose intolerance develop over weeks to months; beta-cell failure and sustained hyperglycemia occur in a subset as animals age.
Research questions: Leptin-resistant obesity, progression from hyperinsulinemia to glucose intolerance, and diabetic complication endpoints in fatty rats.
Limitations: Not all fatty homozygotes become frankly hyperglycemic; the strain carries a leptin-resistance background rather than a defined human T2D gene, and substrain differences affect progression.

Experimental methods

葡萄糖测定

Experimental protocols

大鼠尾静脉血糖测定
Measure rat tail-vein blood glucose using Roche Accutrend Plus test strips and meter.

Reagents and materials

Accutrend Plus 血糖试纸与读数仪
血糖检测耗材与读数平台

References

Model consultation