Mut −/−;Tg INS-CBA-G715V mouse (MUT G715V transgenic rescue)
The INS-CBA-G715V transgene on the Mut −/− background gives reduced MCM activity with moderate methylmalonic acid elevation and a normal lifespan.
Model identity
- Model name
- Mut −/−;Tg INS-CBA-G715V mouse (MUT G715V transgenic rescue)
- Species
- mouse
- Genotype / zygosity
- Mut −/−; Tg INS-CBA-G715V
- Allele
- G715V mutant Mmut transgene under insulin/CBA expression cassette
Biological characteristics
- Research questions
- How partial reduction of MCM activity models intermediate methylmalonic acidemia and its metabolic phenotype.
- Limitations
- Transgene-driven activity reduction depends on expression cassette distribution; metabolite elevation is moderate relative to mut0 mice.