Mmachc tm1.1/tm1.1 cblC mouse (exons 3-4 lacZ replacement)
Mmachc tm1.1/tm1.1 mice survive until approximately E9.5-E15.5 and reproduce features of cblC-type methylmalonic acidemia.
Model identity
- Model name
- Mmachc tm1.1/tm1.1 cblC mouse (exons 3-4 lacZ replacement)
- Species
- mouse
- Genotype / zygosity
- Mmachc tm1.1/tm1.1
- Allele
- exons 3-4 replaced by lacZ cassette
Biological characteristics
- Research questions
- What genetically engineered animal models exist for cblC methylmalonic acidemia and how do they reproduce embryonic disease features.
- Limitations
- Embryonic lethality between E9.5 and E15.5 prevents postnatal study of the homozygous null state.