Tcf7l2 whole-body knockout mouse (reference model)
Homozygous Tcf7l2 knockout mice die shortly after birth with a lack of stem cells in their intestinal crypts.
Model identity
- Model name
- Tcf7l2 whole-body knockout mouse (reference model)
- Species
- mouse
- Genotype / zygosity
- Tcf7l2 −/−
Biological characteristics
- Research questions
- What whole-body loss of Tcf7l2 reveals about T2D risk gene function.
- Limitations
- Neonatal lethality with intestinal phenotype means the whole-body null cannot model adult type 2 diabetes risk; conditional lines are used for metabolic readouts.