alpha cell-specific ZnT8 knockout mouse
Alpha cell-selective ZnT8 null mice displayed unaltered glucose tolerance.
Model identity
- Model name
- alpha cell-specific ZnT8 knockout mouse
- Species
- mouse
- Genotype / zygosity
- ZnT8 deletion restricted to alpha cells
Biological characteristics
- Research questions
- Whether alpha cell ZnT8 deletion affects glucose tolerance and paracrine islet function.
- Limitations
- The negative glucose-tolerance result means this line is used for islet paracrine mechanism comparison rather than as a disease model.