跳至主要内容

疾病

气道高反应性与哮喘

疾病分类：lower respiratory tract disorder／bronchial disorder／respiratory system disorder／human disease／disease by body system or component

疾病介绍

哮喘/气道高反应性以可逆性气流受限、气道炎症与高反应性为特征，多由 2 型（Th2/ILC2）免疫驱动。临床前研究使用经典过敏原致敏-激发、固有免疫 2 型炎症、共病与咳嗽变异型以及转基因/突变背景等模型体系。

标准定义来源：MONDO:0004979 asthma · 本体版本 2026-10-06

参考文献

  1. Ma Xin, Ma Xizhi, Li Xiaopo, Ma Long, Peng Xuezhen, Zhou Xiaotao. Toward Precision Modeling of Cough-Variant Asthma: Standardized Murine Models, Multidimensional Evaluation, and Translational Applications. Journal of Asthma and Allergy. 2025.
  2. Gorska Magdalena M. Update on Type 2 Immunity. The Journal of allergy and clinical immunology. 2025.
  3. Leis Kamil, Gałązka Przemysław, Kazik Jakub, Jamrożek Tomasz, Bereźnicka Weronika, Czajkowski Rafał. Resveratrol in the treatment of asthma based on an animal model. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii. 2022.
  4. Jensen-Jarolim Erika, Pali-Schöll Isabella, Roth-Walter Franziska. Outstanding animal studies in allergy I. From asthma to food allergy and anaphylaxis. Current Opinion in Allergy and Clinical Immunology. 2017.
  5. Wu Hang, Tao Rujia, Xie Shitao, Zhou Yao, Xu Jin-Fu, Xia Zhenwei, Su Xiao. Activation of lung megakaryocyte α 7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling. JCI Insight. 2026.
  6. Kong Jingwei, Yang Fan, Bai Minghua, Zong Yuhan, Li Zhuqing, Meng Xianghe, Zhao Xiaoshan, Wang Ji. Airway immune response in the mouse models of obesity-related asthma. Frontiers in Physiology. 2022.
  7. Lloyd Clare M.. Building Better Mouse Models of Asthma. Current allergy and asthma reports. 2007.
  8. Zeng Yuying, Zhang Yun, Huang Xinyan, Song Lizhen, Polsky Katherine, Wu Yifan, Kheradmand Farrah, Guo Yubiao, Green Linda K., Corry David B., Knight John M.. Novel acute hypersensitivity pneumonitis model induced by airway mycosis and high dose lipopolysaccharide. Respiratory Research. 2021.
  9. Sai Junting, Li Haixia, Chun Liu, Li Weike, Song Dongmin, Yi Mingyang, Wang Zhiwan. Modulation of microbiota by traditional Chinese medicine in chronic inflammatory airway disease: a systematic review and meta-analysis of animal studies. Frontiers in Immunology. 2026.
  10. Hanna Megan E., Kartha Navya, LaMantia Andriana, Grayson Mitchell H., Hussain Syed-Rehan A.. Are we there yet? understanding interactions between respiratory viral infections, atopy, and the microbiome. Frontiers in Allergy. 2026.
  11. Luks Vanessa, Burkett Andrew, Turner Lucy, Pakhale Smita. Effect of physical training on airway inflammation in animal models of asthma: a systematic review. BMC Pulmonary Medicine. 2013.
  12. Wang Zhiyuan, Guo Zhenzhen, Wang Yanan, Dai Qianqian, Arif Muhammad Imran, Maiming Aizetiguli, Li Menghua, Maimaitiniyazi Aliya, Wang Xueli, Cui Jianjiang, Qu Shengmeng, Zhao Wen, Ru Liang. Targeting NLRP3 with GDC-2394 ameliorates airway inflammation and smooth muscle hyperplasia in experimental asthma by suppressing the IL-6/JAK2/STAT3 axis. Scientific Reports. 2026.
  13. Veltri Anthony J, Wells Anthony J, Baus Magdaline, Mathur Sameer K, Samarasinghe Amali E. Single-cell and spatial transcriptomics define eosinophil heterogeneity during influenza A virus–induced exacerbation of fungal allergic asthma in C57BL/6 mice. Journal of Leukocyte Biology. 2026.
  14. Camargo Leandro do Nascimento, Righetti Renato Fraga, Tibério Iolanda de Fátima Lopes Calvo, Grieve David J.. Neutrophil Extracellular Traps at the Asthma + COPD Interface: Mechanisms, Experimental Models, and Therapeutic Targeting. Cells. 2026.
  15. Upadhyay Priya, Wu Ching-Wen, Pham Alexa, Zeki Amir A., Royer Christopher M., Kodavanti Urmila P., Takeuchi Minoru, Bayram Hasan, Pinkerton Kent E.. Animal Models and Mechanisms of Tobacco Smoke-induced Chronic Obstructive Pulmonary Disease (COPD). Journal of toxicology and environmental health. Part B, Critical reviews. 2023.
  16. Hu Hang, Wang Xing, Guo Linlin, Zeng Ziling, Tang Hongmei, Zhang Yun, Duan Jiayao, Wang Kaijin. α-Cyperone targets the PAK1-JNK/NF-κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model. International Journal of Molecular Medicine. 2026.
  17. Miller Madelyn H., Shehat Michael G., Alcedo Karel P., Spinel Lina P., Soulakova Julia, Tigno-Aranjuez Justine T.. RIP2 Promotes House Dust Mite-induced Allergic Airway Inflammation. Journal of leukocyte biology. 2018.
  18. Ruan Zhenan, Sheng Fang, Lin Mali, Wu Shamin, Hu Chuanze, Shao Zhuoqing, Hu Honghua, Xu Lidan. Gut microbiota in asthma: mechanisms, clinical evidence, and therapeutic opportunities. Frontiers in Cellular and Infection Microbiology. 2026.
  19. Zouein Joseph, Que Loretta G., Ingram Jennifer L.. Obesity-driven airway eosinophilia and neutrophilia in asthma. The Journal of asthma : official journal of the Association for the Care of Asthma. 2025.
  20. Salamone Isabella M., Tian Peixin, Qi Zining, Zhao Jiaqi, Zhang Li, Tan Qilong, Li Jinghui, Michael Ashley N., Thornburg Alexis G., Sakabe Noboru J., Minogue Mark, Weber Zachary T., Chen Bohao, Ciszewski Cezary, He Xin, Shah Hardik, Vercelli Donata, Ober Carole, Lin Hening, Liu Zhonghua, Nóbrega Marcelo A., Liu Xuanyao. Trans-regulatory gene mapping prioritizes disease drivers in asthma. Cell. 2026.

适用模型

常用模型严格来自已发布且已验证的疾病—模型关联。

模型咨询