疾病
阿尔茨海默病
疾病分类:dementia/psychiatric disorder/cognitive disorder/central nervous system disorder/nervous system disorder/neurodegenerative disease
疾病介绍
阿尔茨海默病是一种进展性神经退行性疾病,多个脑区的神经细胞功能受损并死亡,逐渐影响记忆、语言等认知功能。
标准定义来源:MONDO:0004975 Alzheimer disease · 本体版本 2026-10-06
参考文献
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- El Hajjar Jida, Chatoo Wassim, Hanna Roy, Nkanza Patrick, Tétreault Nicolas, Tse Yiu Chung, Wong Tak Pan, Abdouh Mohamed, Bernier Gilbert. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1 +/− mice. Scientific Reports. 2019.
- Babygirija Reji, Illiano Julia A., Sonsalla Michelle M., Zhu Grace, Jabbarpour Christopher Retter, Mathew Twinkle, Molkentin Tristan, Peterson Meredith, Winder Carolyn, Nair Advaith Ravi Krishnan, Xiao Fan, Wolter Justin M., Lamming Dudley W., Harris David A.. Sleeve Gastrectomy Improves Metabolic Health, Cognition, and Alzheimer's Disease Pathology in 3xTG Mice. Aging Cell. 2026.
- Boyanova Sevda, Katsouri Loukia, Krupic Julija, Hair Kaitlyn, Wang Szu-Han, Wiseman Frances K.. Considerations for the selection and phenotyping of mouse models for the study of Alzheimer’s disease. STAR Protocols. 2026.
- Dragomir Adrian-Florentin, Zugravu Aurelian, Stoleru Smaranda, Poenaru Elena, Dumitrescu Maria Carina, Albu George, Tomescu Teodora-Nicola, Ivan Gabriela Raluca, Lacatus Maria Georgiana, Barbu Aurelia Cristiana, Fratea Silvia, Coman Oana Andreia, Fulga Ion, Guo Xiangyu. Behavioral Paradigms and Methodological Variability in Aluminum Chloride-Induced Rat Models of Alzheimer’s Disease: A Structured Review. Biology. 2026.
- Khan Nadeemullah, De Somnath, Boddu Suhasini, Pravala Navya. Experimental and translational models of Alzheimer’s disease: From neurodegeneration to novel therapeutic insights. The Journal of Prevention of Alzheimer's Disease. 2026.
- Gecili İbrahim, Ertuğrul Muhammed Sait, Okkay Irmak Ferah, Şenol Onur, Okkay Ufuk, Özkaraca Mustafa, Al-Yaqoobi Ziadoon, Bayram Cemil, Abd El-Aty A. M., Taghizadehghalehjoughi Ali, Hacımüftüoğlu Ahmet, Stanciu Gabriela Dumitrița. Early Neuroprotective Effects of Erucic Acid and Gentisic Acid on Hippocampal Glutamate Concentrations and Alzheimer-like Molecular Alterations in an Intracerebroventricular Streptozotocin Rat Model. Pharmaceuticals. 2026.
- Cai Mudan, Lee Jun-Hwan, Yang Eun Jin. Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer’s disease animal model. Journal of Neuroinflammation. 2019.
- Pattanayak Arindam, Firdous Sayed Mohammed. The 3xTg-AD Mouse Model: A Comprehensive Tool for Understanding Alzheimer’s Disease. Cellular and Molecular Neurobiology. 2026.
- Niño-Rivero Sofía, Cabral Rossana, Fleitas Jazmín, Alcalde-Ahlig Lucía, Castaño Eduardo M., Morelli Laura, McGregor Ronald, Galeano Pablo, Lagos Patricia, Marco-Contelles José. Temporal Progression of Recognition Memory Impairment, Astrogliosis, and Cholinergic Dysfunction in the Streptozotocin Rat Model of Sporadic Alzheimer’s Disease. International Journal of Molecular Sciences. 2025.
- Świątek Grzegorz, Nowakowska-Gołacka Jowita, Słomińska-Wojewódzka Monika, Glac Wojciech, Harackiewicz Oliwia, Kurowska-Rucińska Ewelina, Wrona Danuta, Vasudevan Sona, Tanaka Masashi. Minocycline Treatment Improves Memory and Reduces Anxiety by Lowering Levels of Brain Amyloid Precursor Protein and Indoleamine 2,3-Dioxygenase in a Rat Model of Streptozotocin-Induced Alzheimer’s Disease. International Journal of Molecular Sciences. 2025.
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适用模型
常用模型严格来自已发布且已验证的疾病—模型关联。
5xFAD 转基因模型
5xFAD 转基因模型用于阿尔茨海默病相关淀粉样病理和神经退行性改变研究。
已验证适用
模型完整资料3xTg-AD 转基因模型
3xTg-AD 转基因模型用于阿尔茨海默病相关淀粉样蛋白与 tau 病理研究。
已验证适用
模型完整资料CC × 5xFAD F1 杂交队列
CC×5xFAD F1 队列用于研究宿主遗传背景对淀粉样病理、胶质细胞反应及轴突损伤表型韧性的修饰作用。
已验证适用
模型完整资料APP/PS1 参考品系(B6;C3-Tg(APPswe,PSEN1dE9)85Dbo/Mmjax)
APP/PS1 作为阿尔茨海默病机制与临床前研究的文献参考模型;其 AD 疾病模型适用性来自 MGI 品系疾病表标注,不代表吉田内部验证、库存或实际实验结果
已验证适用
模型完整资料Tg2576 转基因淀粉样蛋白模型(APP695 Swedish)
APP Swedish 突变过表达驱动的年龄依赖记忆减退与淀粉样斑研究(Tg2576)
已验证适用
模型完整资料APP23 转基因淀粉样蛋白模型(Swedish,神经元启动子)
淀粉样沉积与脑淀粉样血管病(CAA)研究的神经元过表达模型(APP23)
已验证适用
模型完整资料J20 转基因淀粉样蛋白模型(APPSwInd,PDGFB)
J20(APP Swedish+Indiana 双突变,PDGFB 启动子)淀粉样病理与突触毒性研究的参考模型;适用性以 JAX 品系记录及 PMID:10818140 对照研究为限
已验证适用
模型完整资料PDAPP 转基因淀粉样蛋白模型(APP V717F Indiana)
Aβ42 比例升高驱动的渐进淀粉样病理研究(PDAPP V717F)
已验证适用
模型完整资料TgCRND8 转基因淀粉样蛋白模型(Swedish+Indiana,PrP)
早发强烈淀粉样沉积与认知损害范式的干预研究(TgCRND8)
已验证适用
模型完整资料App NL-F 敲入模型(Swedish+Iberian 点突变)
人源化 App 敲入生理水平 Aβ 病理与神经炎症研究(App NL-F)
已验证适用
模型完整资料App NL-G-F 敲入模型(Swedish+Arctic+Iberian)
人源化 App 敲入激进 Aβ 沉积级联研究(App NL-G-F)
已验证适用
模型完整资料Sprague-Dawley ICV-STZ rat
研究星形胶质细胞、AQP4极化分布、Aβ清除与认知功能之间的联系,以及候选干预对这些表型的影响。
已验证适用
模型完整资料APOE4
研究APOE4对外周Aβ脑内转运、血脑屏障及认知表现的影响。
已验证适用
模型完整资料McGill-R-Thy1-APP
纵向研究Aβ积累、空间记忆、脑网络连接及PET代谢或淀粉样信号之间的关系。
已验证适用
模型完整资料App NL
研究App Swedish突变、Aβ寡聚体积累与认知表型之间的关系。
已验证适用
模型完整资料Tg4-42
研究Aβ4-42相关的海马神经发生改变,以及活动条件对齿状回结构和神经元生成的影响。
已验证适用
模型完整资料TgF344-AD
研究早期行为变化、工作记忆与结构或功能脑网络之间的联系,探索影像与认知指标的联合评价。
已验证适用
模型完整资料Wistar ICV-STZ rat
研究脑能量代谢、神经损伤与认知功能的联系,评估候选干预对相关表型的影响。
已验证适用
模型完整资料rTg4510
研究 tau 病理、神经退变及 tau 表达抑制的阶段性影响;不适用于单独评价 Aβ 病理。
已验证适用
模型完整资料